Please use this identifier to cite or link to this item:
https://doi.org/10.1177/0267659119839284
DC Field | Value | |
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dc.title | Carbon dioxide removal using low bicarbonate dialysis in rodents | |
dc.contributor.author | Vu, Lien H | |
dc.contributor.author | Kellum, John A | |
dc.contributor.author | Federspiel, William J | |
dc.contributor.author | Cove, Matthew E | |
dc.date.accessioned | 2019-11-07T07:45:14Z | |
dc.date.available | 2019-11-07T07:45:14Z | |
dc.date.issued | 2019-10-01 | |
dc.identifier.citation | Vu, Lien H, Kellum, John A, Federspiel, William J, Cove, Matthew E (2019-10-01). Carbon dioxide removal using low bicarbonate dialysis in rodents. PERFUSION-UK 34 (7) : 578-583. ScholarBank@NUS Repository. https://doi.org/10.1177/0267659119839284 | |
dc.identifier.issn | 0267-6591 | |
dc.identifier.issn | 1477-111X | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/161785 | |
dc.description.abstract | © The Author(s) 2019. Background: Extracorporeal carbon dioxide removal may be used to manage hypercapnia, but compared to dialysis, it’s not widely available. A recent in vitro study showed that dialysis with low bicarbonate dialysates removes CO2. Objective: To show that bicarbonate dialysis removes CO2 in an animal model to validate in-vitro findings and quantify the effect on arterial pH. Methods: Male Sprague-Dawley hypercapnic rats were dialyzed with either a conventional dialysate (PrismasolTM) or a bicarbonate-free dialysate (Bicarb0). The effect of dialysis on standard blood gases and electrolytes was measured. Results: Partial pressure of CO2 and bicarbonate concentration in blood decreased significantly after exposure to Bicarb0 compared to PrismasolTM (filter outflow values 12.8 vs 81.1 mmHg; p < 0.01 for CO2 and 3.5 vs 22.0 mmol/L; p < 0.01 for bicarbonate). Total CO2 content of blood was reduced by 459 mL/L during dialysis with Bicarb0 (filter inflow 546 ± 91 vs filter outflow 87 ± 52 mL/L; p < 0.01), but was not significantly reduced with PrismasolTM. Conclusions: Bicarbonate dialysis removes CO2 at rates comparable to existing low-flow ECCO2R. | |
dc.language.iso | en | |
dc.publisher | SAGE PUBLICATIONS LTD | |
dc.source | Elements | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Cardiac & Cardiovascular Systems | |
dc.subject | Peripheral Vascular Disease | |
dc.subject | Cardiovascular System & Cardiology | |
dc.subject | extracorporeal carbon dioxide removal | |
dc.subject | hemodialysis | |
dc.subject | hypercapnia | |
dc.subject | EXTRACORPOREAL CO2 REMOVAL | |
dc.subject | VENTILATION | |
dc.subject | DEVICE | |
dc.subject | MODEL | |
dc.type | Article | |
dc.date.updated | 2019-11-07T06:56:20Z | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1177/0267659119839284 | |
dc.description.sourcetitle | PERFUSION-UK | |
dc.description.volume | 34 | |
dc.description.issue | 7 | |
dc.description.page | 578-583 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements Staff Publications |
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File | Description | Size | Format | Access Settings | Version | |
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Carbon dioxide dialysis on rodents.pdf | Published version | 251.47 kB | Adobe PDF | CLOSED | None |
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