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|Title:||Corticosteroids for Dengue - Why Don't They Work?||Authors:||Nguyen T.H.T.
Ngoc Tran V.
tumor necrosis factor alpha
low drug dose
polymerase chain reaction
randomized controlled trial
Gene Expression Profiling
Killer Cells, Natural
|Issue Date:||2013||Citation:||Nguyen T.H.T., Nguyen T.H.Q., Vu T.T., Farrar J., Hoang T.L., Dong T.H.T., Ngoc Tran V., Phung K.L., Wolbers M., Whitehead S.S., Hibberd M.L., Wills B., Simmons C.P. (2013). Corticosteroids for Dengue - Why Don't They Work?. PLoS Neglected Tropical Diseases 7 (12) : e2592. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0002592||Abstract:||Background:Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.Findings:In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels.Conclusion:The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue.||Source Title:||PLoS Neglected Tropical Diseases||URI:||https://scholarbank.nus.edu.sg/handle/10635/161626||ISSN:||19352727||DOI:||10.1371/journal.pntd.0002592|
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