Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pntd.0002592
Title: Corticosteroids for Dengue - Why Don't They Work?
Authors: Nguyen T.H.T.
Nguyen T.H.Q.
Vu T.T.
Farrar J.
Hoang T.L.
Dong T.H.T.
Ngoc Tran V.
Phung K.L.
Wolbers M.
Whitehead S.S.
Hibberd M.L. 
Wills B.
Simmons C.P.
Keywords: corticosteroid
gamma interferon
interleukin 10
interleukin 12p70
interleukin 13
interleukin 1beta
interleukin 2
interleukin 4
interleukin 5
interleukin 6
placebo
prednisolone
tumor necrosis factor alpha
adolescent
article
child
controlled study
dengue
drug megadose
female
gene expression
human
immune response
immunoassay
low drug dose
male
microarray analysis
polymerase chain reaction
randomized controlled trial
school child
Adolescent
Child
Child, Preschool
Cytokines
Dengue
Female
Gene Expression Profiling
Humans
Immunologic Factors
Immunomodulation
Killer Cells, Natural
Male
Placebos
Prednisolone
T-Lymphocytes, Cytotoxic
Treatment Failure
Vietnam
Young Adult
Issue Date: 2013
Citation: Nguyen T.H.T., Nguyen T.H.Q., Vu T.T., Farrar J., Hoang T.L., Dong T.H.T., Ngoc Tran V., Phung K.L., Wolbers M., Whitehead S.S., Hibberd M.L., Wills B., Simmons C.P. (2013). Corticosteroids for Dengue - Why Don't They Work?. PLoS Neglected Tropical Diseases 7 (12) : e2592. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0002592
Abstract: Background:Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.Findings:In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels.Conclusion:The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue.
Source Title: PLoS Neglected Tropical Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/161626
ISSN: 19352727
DOI: 10.1371/journal.pntd.0002592
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