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https://doi.org/10.1371/journal.pntd.0002592
| Title: | Corticosteroids for Dengue - Why Don't They Work? | Authors: | Nguyen T.H.T. Nguyen T.H.Q. Vu T.T. Farrar J. Hoang T.L. Dong T.H.T. Ngoc Tran V. Phung K.L. Wolbers M. Whitehead S.S. Hibberd M.L. Wills B. Simmons C.P. |
Keywords: | corticosteroid gamma interferon interleukin 10 interleukin 12p70 interleukin 13 interleukin 1beta interleukin 2 interleukin 4 interleukin 5 interleukin 6 placebo prednisolone tumor necrosis factor alpha adolescent article child controlled study dengue drug megadose female gene expression human immune response immunoassay low drug dose male microarray analysis polymerase chain reaction randomized controlled trial school child Adolescent Child Child, Preschool Cytokines Dengue Female Gene Expression Profiling Humans Immunologic Factors Immunomodulation Killer Cells, Natural Male Placebos Prednisolone T-Lymphocytes, Cytotoxic Treatment Failure Vietnam Young Adult |
Issue Date: | 2013 | Citation: | Nguyen T.H.T., Nguyen T.H.Q., Vu T.T., Farrar J., Hoang T.L., Dong T.H.T., Ngoc Tran V., Phung K.L., Wolbers M., Whitehead S.S., Hibberd M.L., Wills B., Simmons C.P. (2013). Corticosteroids for Dengue - Why Don't They Work?. PLoS Neglected Tropical Diseases 7 (12) : e2592. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0002592 | Rights: | CC0 1.0 Universal | Abstract: | Background:Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.Findings:In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels.Conclusion:The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue. | Source Title: | PLoS Neglected Tropical Diseases | URI: | https://scholarbank.nus.edu.sg/handle/10635/161626 | ISSN: | 19352727 | DOI: | 10.1371/journal.pntd.0002592 | Rights: | CC0 1.0 Universal |
| Appears in Collections: | Elements Staff Publications |
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