Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pntd.0002592
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dc.titleCorticosteroids for Dengue - Why Don't They Work?
dc.contributor.authorNguyen T.H.T.
dc.contributor.authorNguyen T.H.Q.
dc.contributor.authorVu T.T.
dc.contributor.authorFarrar J.
dc.contributor.authorHoang T.L.
dc.contributor.authorDong T.H.T.
dc.contributor.authorNgoc Tran V.
dc.contributor.authorPhung K.L.
dc.contributor.authorWolbers M.
dc.contributor.authorWhitehead S.S.
dc.contributor.authorHibberd M.L.
dc.contributor.authorWills B.
dc.contributor.authorSimmons C.P.
dc.date.accessioned2019-11-06T09:27:17Z
dc.date.available2019-11-06T09:27:17Z
dc.date.issued2013
dc.identifier.citationNguyen T.H.T., Nguyen T.H.Q., Vu T.T., Farrar J., Hoang T.L., Dong T.H.T., Ngoc Tran V., Phung K.L., Wolbers M., Whitehead S.S., Hibberd M.L., Wills B., Simmons C.P. (2013). Corticosteroids for Dengue - Why Don't They Work?. PLoS Neglected Tropical Diseases 7 (12) : e2592. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pntd.0002592
dc.identifier.issn19352727
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/161626
dc.description.abstractBackground:Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue.Findings:In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels.Conclusion:The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue.
dc.rightsCC0 1.0 Universal
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.sourceUnpaywall 20191101
dc.subjectcorticosteroid
dc.subjectgamma interferon
dc.subjectinterleukin 10
dc.subjectinterleukin 12p70
dc.subjectinterleukin 13
dc.subjectinterleukin 1beta
dc.subjectinterleukin 2
dc.subjectinterleukin 4
dc.subjectinterleukin 5
dc.subjectinterleukin 6
dc.subjectplacebo
dc.subjectprednisolone
dc.subjecttumor necrosis factor alpha
dc.subjectadolescent
dc.subjectarticle
dc.subjectchild
dc.subjectcontrolled study
dc.subjectdengue
dc.subjectdrug megadose
dc.subjectfemale
dc.subjectgene expression
dc.subjecthuman
dc.subjectimmune response
dc.subjectimmunoassay
dc.subjectlow drug dose
dc.subjectmale
dc.subjectmicroarray analysis
dc.subjectpolymerase chain reaction
dc.subjectrandomized controlled trial
dc.subjectschool child
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCytokines
dc.subjectDengue
dc.subjectFemale
dc.subjectGene Expression Profiling
dc.subjectHumans
dc.subjectImmunologic Factors
dc.subjectImmunomodulation
dc.subjectKiller Cells, Natural
dc.subjectMale
dc.subjectPlacebos
dc.subjectPrednisolone
dc.subjectT-Lymphocytes, Cytotoxic
dc.subjectTreatment Failure
dc.subjectVietnam
dc.subjectYoung Adult
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1371/journal.pntd.0002592
dc.description.sourcetitlePLoS Neglected Tropical Diseases
dc.description.volume7
dc.description.issue12
dc.description.pagee2592
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