Please use this identifier to cite or link to this item:
https://doi.org/10.1371/journal.pone.0104568
| Title: | Pleiotropic functions for transcription factor Zscan10 | Authors: | Kraus P. Sivakamasundari V. Yu H.B. Xing X. Lim S.L. Adler T. Pimentel J.A.A. Becker L. Bohla A. Garrett L. Hans W. Hölter S.M. Janas E. Moreth K. Prehn C. Puk O. Rathkolb B. Rozman J. Adamski J. Bekeredjian R. Busch D.H. Graw J. Klingenspor M. Klopstock T. Neff F. Ollert M. Stoeger T. Yildrim A.Ö. Eickelberg O. Wolf E. Wurst W. Fuchs H. Gailus-Durner V. De Angelis M.H. Lufkin T. Stanton L.W. |
Keywords: | start codon transcription factor ZFP206 protein, mouse animal animal behavior body weight bone bone density cytology eye female gene expression regulation genetics growth, development and aging homozygote male metabolism mouse mutation organ size physiology pleiotropy pluripotent stem cell pregnancy start codon weaning Animals Behavior, Animal Body Weight Bone and Bones Bone Density Codon, Initiator Eye Female Gene Expression Regulation Genetic Pleiotropy Homozygote Male Mice Mutation Organ Size Pluripotent Stem Cells Pregnancy Transcription Factors Weaning |
Issue Date: | 2014 | Citation: | Kraus P., Sivakamasundari V., Yu H.B., Xing X., Lim S.L., Adler T., Pimentel J.A.A., Becker L., Bohla A., Garrett L., Hans W., Hölter S.M., Janas E., Moreth K., Prehn C., Puk O., Rathkolb B., Rozman J., Adamski J., Bekeredjian R., Busch D.H., Graw J., Klingenspor M., Klopstock T., Neff F., Ollert M., Stoeger T., Yildrim A.Ö., Eickelberg O., Wolf E., Wurst W., Fuchs H., Gailus-Durner V., De Angelis M.H., Lufkin T., Stanton L.W. (2014). Pleiotropic functions for transcription factor Zscan10. PLoS ONE 9 (8) : e104568. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0104568 | Rights: | Attribution 4.0 International | Abstract: | The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo . Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported by the nature of Zscan10 expression in midgestation embryos and adults suggesting a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof. © 2014 Kraus et al. | Source Title: | PLoS ONE | URI: | https://scholarbank.nus.edu.sg/handle/10635/161391 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0104568 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Staff Publications Elements |
Show full item record
Files in This Item:
| File | Description | Size | Format | Access Settings | Version | |
|---|---|---|---|---|---|---|
| 10_1371_journal_pone_0104568.pdf | 3.25 MB | Adobe PDF | OPEN | Published | View/Download |
This item is licensed under a Creative Commons License
