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Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0104568
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dc.titlePleiotropic functions for transcription factor Zscan10
dc.contributor.authorKraus P.
dc.contributor.authorSivakamasundari V.
dc.contributor.authorYu H.B.
dc.contributor.authorXing X.
dc.contributor.authorLim S.L.
dc.contributor.authorAdler T.
dc.contributor.authorPimentel J.A.A.
dc.contributor.authorBecker L.
dc.contributor.authorBohla A.
dc.contributor.authorGarrett L.
dc.contributor.authorHans W.
dc.contributor.authorHölter S.M.
dc.contributor.authorJanas E.
dc.contributor.authorMoreth K.
dc.contributor.authorPrehn C.
dc.contributor.authorPuk O.
dc.contributor.authorRathkolb B.
dc.contributor.authorRozman J.
dc.contributor.authorAdamski J.
dc.contributor.authorBekeredjian R.
dc.contributor.authorBusch D.H.
dc.contributor.authorGraw J.
dc.contributor.authorKlingenspor M.
dc.contributor.authorKlopstock T.
dc.contributor.authorNeff F.
dc.contributor.authorOllert M.
dc.contributor.authorStoeger T.
dc.contributor.authorYildrim A.Ö.
dc.contributor.authorEickelberg O.
dc.contributor.authorWolf E.
dc.contributor.authorWurst W.
dc.contributor.authorFuchs H.
dc.contributor.authorGailus-Durner V.
dc.contributor.authorDe Angelis M.H.
dc.contributor.authorLufkin T.
dc.contributor.authorStanton L.W.
dc.date.accessioned2019-11-05T00:34:06Z
dc.date.available2019-11-05T00:34:06Z
dc.date.issued2014
dc.identifier.citationKraus P., Sivakamasundari V., Yu H.B., Xing X., Lim S.L., Adler T., Pimentel J.A.A., Becker L., Bohla A., Garrett L., Hans W., Hölter S.M., Janas E., Moreth K., Prehn C., Puk O., Rathkolb B., Rozman J., Adamski J., Bekeredjian R., Busch D.H., Graw J., Klingenspor M., Klopstock T., Neff F., Ollert M., Stoeger T., Yildrim A.Ö., Eickelberg O., Wolf E., Wurst W., Fuchs H., Gailus-Durner V., De Angelis M.H., Lufkin T., Stanton L.W. (2014). Pleiotropic functions for transcription factor Zscan10. PLoS ONE 9 (8) : e104568. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0104568
dc.identifier.issn1932-6203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/161391
dc.description.abstractThe transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo . Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported by the nature of Zscan10 expression in midgestation embryos and adults suggesting a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof. © 2014 Kraus et al.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20191101
dc.subjectstart codon
dc.subjecttranscription factor
dc.subjectZFP206 protein, mouse
dc.subjectanimal
dc.subjectanimal behavior
dc.subjectbody weight
dc.subjectbone
dc.subjectbone density
dc.subjectcytology
dc.subjecteye
dc.subjectfemale
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjectgrowth, development and aging
dc.subjecthomozygote
dc.subjectmale
dc.subjectmetabolism
dc.subjectmouse
dc.subjectmutation
dc.subjectorgan size
dc.subjectphysiology
dc.subjectpleiotropy
dc.subjectpluripotent stem cell
dc.subjectpregnancy
dc.subjectstart codon
dc.subjectweaning
dc.subjectAnimals
dc.subjectBehavior, Animal
dc.subjectBody Weight
dc.subjectBone and Bones
dc.subjectBone Density
dc.subjectCodon, Initiator
dc.subjectEye
dc.subjectFemale
dc.subjectGene Expression Regulation
dc.subjectGenetic Pleiotropy
dc.subjectHomozygote
dc.subjectMale
dc.subjectMice
dc.subjectMutation
dc.subjectOrgan Size
dc.subjectPluripotent Stem Cells
dc.subjectPregnancy
dc.subjectTranscription Factors
dc.subjectWeaning
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1371/journal.pone.0104568
dc.description.sourcetitlePLoS ONE
dc.description.volume9
dc.description.issue8
dc.description.pagee104568
dc.published.statePublished
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