Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0197226
Title: One-year mortality after recovery from critical illness: A retrospective cohort study
Authors: Lokhandwala S.
McCague N.
Chahin A.
Escobar B.
Feng M. 
Ghassemi M.M.
Stone D.J.
Celi L.A.
Keywords: vasoactive agent
adult
aged
aging
Article
artificial ventilation
chronic obstructive lung disease
cohort analysis
congestive heart failure
critical illness
end stage renal disease
female
hospital admission
human
liver cirrhosis
longitudinal study
major clinical study
male
malignant neoplasm
mortality
prognosis
renal replacement therapy
retrospective study
risk factor
sepsis
survival
chronic kidney failure
chronic obstructive lung disease
critical illness
disease free survival
fibrosis
heart failure
intensive care
middle aged
survival rate
Aged
Critical Care
Critical Illness
Disease-Free Survival
Female
Fibrosis
Heart Failure
Humans
Kidney Failure, Chronic
Longitudinal Studies
Male
Middle Aged
Mortality
Pulmonary Disease, Chronic Obstructive
Renal Replacement Therapy
Retrospective Studies
Survival Rate
Issue Date: 2018
Citation: Lokhandwala S., McCague N., Chahin A., Escobar B., Feng M., Ghassemi M.M., Stone D.J., Celi L.A. (2018). One-year mortality after recovery from critical illness: A retrospective cohort study. PLoS ONE 13 (5) : e0197226. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0197226
Abstract: Rationale Factors associated with one-year mortality after recovery from critical illness are not well understood. Clinicians generally lack information regarding post-hospital discharge outcomes of patients from the intensive care unit, which may be important when counseling patients and families. Objective We sought to determine which factors among patients who survived for at least 30 days post-ICU admission are associated with one-year mortality. Methods Single-center, longitudinal retrospective cohort study of all ICU patients admitted to a tertiary-care academic medical center from 2001–2012 who survived 30 days from ICU admission. Cox’s proportional hazards model was used to identify the variables that are associated with one-year mortality. The primary outcome was one-year mortality. Results 32,420 patients met the inclusion criteria and were included in the study. Among patients who survived to 30 days, 28,583 (88.2%) survived for greater than one year, whereas 3,837 (11.8%) did not. Variables associated with decreased one-year survival include: increased age, malignancy, number of hospital admissions within the prior year, duration of mechanical ventilation and vasoactive agent use, sepsis, history of congestive heart failure, end-stage renal disease, cirrhosis, chronic obstructive pulmonary disease, and the need for renal replacement therapy. Numerous effect modifications between these factors were found. Conclusion Among survivors of critical illness, a significant number survive less than one year. More research is needed to help clinicians accurately identify those patients who, despite surviving their acute illness, are likely to suffer one-year mortality, and thereby to improve the quality of the decisions and care that impact this outcome. © 2018 Lokhandwala et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Title: PLoS ONE
URI: https://scholarbank.nus.edu.sg/handle/10635/161228
ISSN: 19326203
DOI: 10.1371/journal.pone.0197226
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