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https://doi.org/10.1371/journal.pone.0197226
Title: | One-year mortality after recovery from critical illness: A retrospective cohort study | Authors: | Lokhandwala S. McCague N. Chahin A. Escobar B. Feng M. Ghassemi M.M. Stone D.J. Celi L.A. |
Keywords: | vasoactive agent adult aged aging Article artificial ventilation chronic obstructive lung disease cohort analysis congestive heart failure critical illness end stage renal disease female hospital admission human liver cirrhosis longitudinal study major clinical study male malignant neoplasm mortality prognosis renal replacement therapy retrospective study risk factor sepsis survival chronic kidney failure chronic obstructive lung disease critical illness disease free survival fibrosis heart failure intensive care middle aged survival rate Aged Critical Care Critical Illness Disease-Free Survival Female Fibrosis Heart Failure Humans Kidney Failure, Chronic Longitudinal Studies Male Middle Aged Mortality Pulmonary Disease, Chronic Obstructive Renal Replacement Therapy Retrospective Studies Survival Rate |
Issue Date: | 2018 | Citation: | Lokhandwala S., McCague N., Chahin A., Escobar B., Feng M., Ghassemi M.M., Stone D.J., Celi L.A. (2018). One-year mortality after recovery from critical illness: A retrospective cohort study. PLoS ONE 13 (5) : e0197226. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0197226 | Rights: | Attribution 4.0 International | Abstract: | Rationale Factors associated with one-year mortality after recovery from critical illness are not well understood. Clinicians generally lack information regarding post-hospital discharge outcomes of patients from the intensive care unit, which may be important when counseling patients and families. Objective We sought to determine which factors among patients who survived for at least 30 days post-ICU admission are associated with one-year mortality. Methods Single-center, longitudinal retrospective cohort study of all ICU patients admitted to a tertiary-care academic medical center from 2001–2012 who survived 30 days from ICU admission. Cox’s proportional hazards model was used to identify the variables that are associated with one-year mortality. The primary outcome was one-year mortality. Results 32,420 patients met the inclusion criteria and were included in the study. Among patients who survived to 30 days, 28,583 (88.2%) survived for greater than one year, whereas 3,837 (11.8%) did not. Variables associated with decreased one-year survival include: increased age, malignancy, number of hospital admissions within the prior year, duration of mechanical ventilation and vasoactive agent use, sepsis, history of congestive heart failure, end-stage renal disease, cirrhosis, chronic obstructive pulmonary disease, and the need for renal replacement therapy. Numerous effect modifications between these factors were found. Conclusion Among survivors of critical illness, a significant number survive less than one year. More research is needed to help clinicians accurately identify those patients who, despite surviving their acute illness, are likely to suffer one-year mortality, and thereby to improve the quality of the decisions and care that impact this outcome. © 2018 Lokhandwala et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | Source Title: | PLoS ONE | URI: | https://scholarbank.nus.edu.sg/handle/10635/161228 | ISSN: | 19326203 | DOI: | 10.1371/journal.pone.0197226 | Rights: | Attribution 4.0 International |
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