Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0197226
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dc.titleOne-year mortality after recovery from critical illness: A retrospective cohort study
dc.contributor.authorLokhandwala S.
dc.contributor.authorMcCague N.
dc.contributor.authorChahin A.
dc.contributor.authorEscobar B.
dc.contributor.authorFeng M.
dc.contributor.authorGhassemi M.M.
dc.contributor.authorStone D.J.
dc.contributor.authorCeli L.A.
dc.date.accessioned2019-11-01T08:15:15Z
dc.date.available2019-11-01T08:15:15Z
dc.date.issued2018
dc.identifier.citationLokhandwala S., McCague N., Chahin A., Escobar B., Feng M., Ghassemi M.M., Stone D.J., Celi L.A. (2018). One-year mortality after recovery from critical illness: A retrospective cohort study. PLoS ONE 13 (5) : e0197226. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0197226
dc.identifier.issn19326203
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/161228
dc.description.abstractRationale Factors associated with one-year mortality after recovery from critical illness are not well understood. Clinicians generally lack information regarding post-hospital discharge outcomes of patients from the intensive care unit, which may be important when counseling patients and families. Objective We sought to determine which factors among patients who survived for at least 30 days post-ICU admission are associated with one-year mortality. Methods Single-center, longitudinal retrospective cohort study of all ICU patients admitted to a tertiary-care academic medical center from 2001–2012 who survived 30 days from ICU admission. Cox’s proportional hazards model was used to identify the variables that are associated with one-year mortality. The primary outcome was one-year mortality. Results 32,420 patients met the inclusion criteria and were included in the study. Among patients who survived to 30 days, 28,583 (88.2%) survived for greater than one year, whereas 3,837 (11.8%) did not. Variables associated with decreased one-year survival include: increased age, malignancy, number of hospital admissions within the prior year, duration of mechanical ventilation and vasoactive agent use, sepsis, history of congestive heart failure, end-stage renal disease, cirrhosis, chronic obstructive pulmonary disease, and the need for renal replacement therapy. Numerous effect modifications between these factors were found. Conclusion Among survivors of critical illness, a significant number survive less than one year. More research is needed to help clinicians accurately identify those patients who, despite surviving their acute illness, are likely to suffer one-year mortality, and thereby to improve the quality of the decisions and care that impact this outcome. © 2018 Lokhandwala et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.sourceUnpaywall 20191101
dc.subjectvasoactive agent
dc.subjectadult
dc.subjectaged
dc.subjectaging
dc.subjectArticle
dc.subjectartificial ventilation
dc.subjectchronic obstructive lung disease
dc.subjectcohort analysis
dc.subjectcongestive heart failure
dc.subjectcritical illness
dc.subjectend stage renal disease
dc.subjectfemale
dc.subjecthospital admission
dc.subjecthuman
dc.subjectliver cirrhosis
dc.subjectlongitudinal study
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmalignant neoplasm
dc.subjectmortality
dc.subjectprognosis
dc.subjectrenal replacement therapy
dc.subjectretrospective study
dc.subjectrisk factor
dc.subjectsepsis
dc.subjectsurvival
dc.subjectchronic kidney failure
dc.subjectchronic obstructive lung disease
dc.subjectcritical illness
dc.subjectdisease free survival
dc.subjectfibrosis
dc.subjectheart failure
dc.subjectintensive care
dc.subjectmiddle aged
dc.subjectsurvival rate
dc.subjectAged
dc.subjectCritical Care
dc.subjectCritical Illness
dc.subjectDisease-Free Survival
dc.subjectFemale
dc.subjectFibrosis
dc.subjectHeart Failure
dc.subjectHumans
dc.subjectKidney Failure, Chronic
dc.subjectLongitudinal Studies
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMortality
dc.subjectPulmonary Disease, Chronic Obstructive
dc.subjectRenal Replacement Therapy
dc.subjectRetrospective Studies
dc.subjectSurvival Rate
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1371/journal.pone.0197226
dc.description.sourcetitlePLoS ONE
dc.description.volume13
dc.description.issue5
dc.description.pagee0197226
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