Please use this identifier to cite or link to this item: https://doi.org/10.1080/10428194.2019.1607330
Title: Epstein–Barr virus-encoded LMP1 induces ectopic CD137 expression on Hodgkin and Reed–Sternberg cells via the PI3K-AKT-mTOR pathway
Authors: SNEHA PRIYA ARAVINTH 
Rajendran, S 
Li, Y 
Wu, M 
Yi Wong, AH 
Schwarz, H 
Keywords: CD137
EBV
Hodgkin lymphoma
LMP1
Issue Date: 1-Jan-2019
Citation: SNEHA PRIYA ARAVINTH, Rajendran, S, Li, Y, Wu, M, Yi Wong, AH, Schwarz, H (2019-01-01). Epstein–Barr virus-encoded LMP1 induces ectopic CD137 expression on Hodgkin and Reed–Sternberg cells via the PI3K-AKT-mTOR pathway. Leukemia and Lymphoma : 1-8. ScholarBank@NUS Repository. https://doi.org/10.1080/10428194.2019.1607330
Abstract: © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. CD137 is a potent co-stimulatory molecule on activated T cells, and its ligand (CD137L) is expressed on antigen presenting cells (APC). Ectopic expression of CD137 has been identified on Hodgkin Reed–Sternberg (HRS) cells, the malignant cells in Hodgkin Lymphoma (HL), and CD137 on HRS cells was found to support growth of HRS cells and escape from immune surveillance. HRS cells are mostly derived from B cells, which poses the question of how B cells acquire ectopic CD137 expression during the transformation process. HL is associated with Epstein–Barr virus (EBV) infection. We show that the EBV latent membrane protein 1 (LMP1) induces expression of CD137 in HRS cell lines. In a HL tissue microarray, 96% of the CD137-positive HL cases stained positive for LMP1. LMP1 utilizes the PI3K-AKT-mTOR pathway for inducing CD137 expression. These findings support the role of EBV in HL pathogenesis.
Source Title: Leukemia and Lymphoma
URI: https://scholarbank.nus.edu.sg/handle/10635/155346
ISSN: 1042-8194
1029-2403
DOI: 10.1080/10428194.2019.1607330
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