Please use this identifier to cite or link to this item: https://doi.org/10.1098/rsif.2018.0799
Title: Bioinspired polydopamine and polyphenol tannic acid functionalized titanium suppress osteoclast differentiation: a facile and efficient strategy to regulate osteoclast activity at bone-implant interface
Authors: Steffi, Chris 
Shi, Zhilong 
Kong, Chee Hoe
Wang, Wilson 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
titanium
osteoporosis
polydopamine
polyphenol tannic acid
osteoclast
NANO-TOPOGRAPHY
SURFACE
COATINGS
PEPTIDE
PHOSPHATASE
DEPOSITION
STABILITY
FIXATION
Issue Date: 1-Mar-2019
Publisher: ROYAL SOC
Citation: Steffi, Chris, Shi, Zhilong, Kong, Chee Hoe, Wang, Wilson (2019-03-01). Bioinspired polydopamine and polyphenol tannic acid functionalized titanium suppress osteoclast differentiation: a facile and efficient strategy to regulate osteoclast activity at bone-implant interface. JOURNAL OF THE ROYAL SOCIETY INTERFACE 16 (152). ScholarBank@NUS Repository. https://doi.org/10.1098/rsif.2018.0799
Abstract: © 2019 The Author(s) Published by the Royal Society. All rights reserved. Osseointegration of metallic implants in porous osteoporotic bone remains a challenge. Surface modification of implants to reduce peri-implant osteoclastic bone resorption was explored in the study. Bioinspired polydopamine (pDOP) and polyphenol tannic acid (pTAN) are nature-derived universal coating systems that have emerged either as a sole coating or ad-layer for biomolecular conjugation on different biomaterials. The effects pDOP and pTAN on osteoclast development have not been reported before. In this study, osteoclast development was investigated on titanium (Ti) substrates coated with pDOP (Ti-pDOP) and pTAN (Ti-pTAN). The results showed that Ti-pDOP and Ti-pTAN coating reduced tartrate-resistant acid phosphatase activity and osteoclast cell number as compared with pristine Ti. Intriguingly, the reduction was higher on Ti-pTAN than on Ti-pDOP. Economical and biocompatible tannic acid serves as a superior coating in decreasing osteoclast activity when compared with that of pDOP coating and could be used to modulate osteoclast activity at bone-implant interfaces.
Source Title: JOURNAL OF THE ROYAL SOCIETY INTERFACE
URI: https://scholarbank.nus.edu.sg/handle/10635/155119
ISSN: 1742-5689
1742-5662
DOI: 10.1098/rsif.2018.0799
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