Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-02257-3
Title: Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions
Authors: Cao, Fan 
Fang, Yiwen 
Tan, Hong Kee 
Goh, Yufen 
Choy, Jocelyn Yeen Hui
Koh, Bryan Thean Howe
Tan, Jiong Hao
Bertin, Nicolas
Ramadass, Aroul
Hunter, Ewan
Green, Jayne
Salter, Matthew
Akoulitchev, Alexandre
Wang, Wilson 
Chng, Wee Joo 
Tenen, Daniel G 
Fullwood, Melissa J 
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
CHROMOSOME CONFORMATION CAPTURE
CELL IDENTITY
GENOME
ORGANIZATION
INHIBITION
MELANOMA
DISEASE
ATLAS
Issue Date: 19-May-2017
Publisher: NATURE PUBLISHING GROUP
Citation: Cao, Fan, Fang, Yiwen, Tan, Hong Kee, Goh, Yufen, Choy, Jocelyn Yeen Hui, Koh, Bryan Thean Howe, Tan, Jiong Hao, Bertin, Nicolas, Ramadass, Aroul, Hunter, Ewan, Green, Jayne, Salter, Matthew, Akoulitchev, Alexandre, Wang, Wilson, Chng, Wee Joo, Tenen, Daniel G, Fullwood, Melissa J (2017-05-19). Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions. SCIENTIFIC REPORTS 7 (1). ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-02257-3
Abstract: © 2017 The Author(s). Stretched histone regions, such as super-enhancers and broad H3K4me3 domains, are associated with maintenance of cell identity and cancer. We connected super-enhancers and broad H3K4me3 domains in the K562 chronic myelogenous leukemia cell line as well as the MCF-7 breast cancer cell line with chromatin interactions. Super-enhancers and broad H3K4me3 domains showed higher association with chromatin interactions than their typical counterparts. Interestingly, we identified a subset of super-enhancers that overlap with broad H3K4me3 domains and show high association with cancer-associated genes including tumor suppressor genes. Besides cell lines, we could observe chromatin interactions by a Chromosome Conformation Capture (3C)-based method, in primary human samples. Several chromatin interactions involving super-enhancers and broad H3K4me3 domains are constitutive and can be found in both cancer and normal samples. Taken together, these results reveal a new layer of complexity in gene regulation by super-enhancers and broad H3K4me3 domains.
Source Title: SCIENTIFIC REPORTS
URI: https://scholarbank.nus.edu.sg/handle/10635/155112
ISSN: 2045-2322
2045-2322
DOI: 10.1038/s41598-017-02257-3
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