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https://doi.org/10.1212/01.WNL.0000101721.25345.DC
| Title: | Alpha-synuclein haplotypes implicated in risk of Parkinson's disease | Authors: | Tan E.-K. Chai A. Teo Y.Y. Zhao Y. Tan C. Shen H. Chandran V.R. Teoh M.L. Yih Y. Pavanni R. Wong M.C. Puvan K. Lo Y.L. Yap E. |
Issue Date: | 2004 | Publisher: | Lippincott Williams and Wilkins | Citation: | Tan E.-K., Chai A., Teo Y.Y., Zhao Y., Tan C., Shen H., Chandran V.R., Teoh M.L., Yih Y., Pavanni R., Wong M.C., Puvan K., Lo Y.L., Yap E. (2004). Alpha-synuclein haplotypes implicated in risk of Parkinson's disease. Neurology 62 (1) : 128-131. ScholarBank@NUS Repository. https://doi.org/10.1212/01.WNL.0000101721.25345.DC | Abstract: | The authors examined four- and six-loci haplotype constructs (from five single nucleotide polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with Parkinson's disease (PD) and controls in an ethnic Chinese population. Logistic regression analysis demonstrated an association of NACP-Rep1 (p = 0.002) and L478 (p < 0.0001) with risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific four-loci and six-loci haplotypes were significantly associated with an increased or decreased risk of PD. | Source Title: | Neurology | URI: | http://scholarbank.nus.edu.sg/handle/10635/150238 | ISSN: | 00283878 | DOI: | 10.1212/01.WNL.0000101721.25345.DC |
| Appears in Collections: | Staff Publications |
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