Please use this identifier to cite or link to this item: https://doi.org/10.1002/mds.26495
Title: Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease
Authors: Foo J.N.
Chung S.J.
Tan L.C.
Liany H.
Ryu H.-S.
Hong M.
Koh T.H.
Irwan I.D.
Au W.-L.
Prakash K.-M.
Aung T. 
Cheng C.-Y. 
Chong S.-A. 
Khor C.C. 
Lee J. 
Tai E.-S. 
Vithana E.N. 
Wong T.-Y. 
Song K.
Liu J. 
Tan E.-K. 
Keywords: Coding variants
Genome-wide association
Human genetics
Parkinson's disease
Sequencing
Issue Date: 2016
Publisher: John Wiley and Sons Inc.
Citation: Foo J.N., Chung S.J., Tan L.C., Liany H., Ryu H.-S., Hong M., Koh T.H., Irwan I.D., Au W.-L., Prakash K.-M., Aung T., Cheng C.-Y., Chong S.-A., Khor C.C., Lee J., Tai E.-S., Vithana E.N., Wong T.-Y., Song K., Liu J., Tan E.-K. (2016). Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease. Movement Disorders 31 (4) : 484-487. ScholarBank@NUS Repository. https://doi.org/10.1002/mds.26495
Abstract: Background: Genome-wide association studies have identified several loci associated with Parkinson's disease (PD). Whole-exome sequencing detects rare coding variants, but their links with PD genome-wide association study loci are unknown. Our objective was to investigate whether nonsynonymous variants in LRRK2 can explain associations at the PD-associated locus tagged by rs1994090. Methods: We sequenced all coding exons of LRRK2 in 453 East Asian samples and evaluated linkage disequilibrium between each nonsynonymous variant and rs1994090. We then tested selected variants and haplotypes for association with PD in 13,581 East Asian samples. Results: Of all the nonsynonymous variants, only p.Gly2385Arg was in moderate linkage disequilibrium with rs1994090 and was observed on haplotypes tagged by the rs1994090-C risk allele. Conditional analyses showed that associations at these 2 variants are not independent. Conclusions: LRRK2 p.Gly2385Arg can explain most if not all of the PD association at rs1994090 in East Asians, but other nonsynonymous variants are independent. � 2016 International Parkinson and Movement Disorder Society.
Source Title: Movement Disorders
URI: http://scholarbank.nus.edu.sg/handle/10635/150115
ISSN: 8853185
DOI: 10.1002/mds.26495
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

4
checked on Aug 19, 2019

WEB OF SCIENCETM
Citations

5
checked on Dec 31, 2018

Page view(s)

105
checked on Aug 15, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.