Please use this identifier to cite or link to this item:
Title: A longitudinal study of non-motor symptom burden in Parkinson's disease after a transition to expert care
Authors: Prakash K.M. 
Nadkarni N.V. 
Lye W.-K. 
Yong M.-H.
Chew L.-M.
Tan E.-K. 
Keywords: Non-motor symptoms
Parkinson's disease
Issue Date: 2015
Publisher: Elsevier Ltd
Citation: Prakash K.M., Nadkarni N.V., Lye W.-K., Yong M.-H., Chew L.-M., Tan E.-K. (2015). A longitudinal study of non-motor symptom burden in Parkinson's disease after a transition to expert care. Parkinsonism and Related Disorders 21 (8) : 843-847. ScholarBank@NUS Repository.
Abstract: Background: Non-motor symptoms (NMS) are common among patients with Parkinson's disease (PD) however little is known about their progression in terms of severity or burden after referral to expert care. Objective: This study was aimed to establish the progression of NMS burden in PD patients after referral to tertiary healthcare centre and factors affecting it. Methods: Newly referred PD patients were prospectively enrolled and follow-up for up to 18 months. Non-motor symptoms scale (NMSS) was used to evaluate the burden of non-motor symptoms. Results: There was a significant median reduction of total NMS burden over the follow-up period. Similarly all NMS domains except domains 2 (sleep/fatigue), 3 (mood/cognition), 6 (gastrointestinal) and 7 (urinary) showed significant median reduction of scores. In the univariate regression analysis, Hoehn & Yahr staging, disease duration, visit, Schwab & England Activities of Daily Living score and UPDRS motor scores were individually predictive of change in total NMS burden. However, in the multivariable regression analysis only the latter three were significantly predictive of change in the total NMS burden. Conclusion: There was a significant reduction of total NMS burden over the study period. The severity of motor and activity of daily living impairments as well as subsequent visit were the best predictors of NMS change. � 2015 Elsevier Ltd.
Source Title: Parkinsonism and Related Disorders
ISSN: 1353-8020
DOI: 10.1016/j.parkreldis.2015.04.017
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Sep 19, 2019


checked on Jul 17, 2019

Page view(s)

checked on Sep 19, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.