Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.parkreldis.2015.04.017
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dc.titleA longitudinal study of non-motor symptom burden in Parkinson's disease after a transition to expert care
dc.contributor.authorPrakash K.M.
dc.contributor.authorNadkarni N.V.
dc.contributor.authorLye W.-K.
dc.contributor.authorYong M.-H.
dc.contributor.authorChew L.-M.
dc.contributor.authorTan E.-K.
dc.date.accessioned2018-11-27T07:23:12Z
dc.date.available2018-11-27T07:23:12Z
dc.date.issued2015
dc.identifier.citationPrakash K.M., Nadkarni N.V., Lye W.-K., Yong M.-H., Chew L.-M., Tan E.-K. (2015). A longitudinal study of non-motor symptom burden in Parkinson's disease after a transition to expert care. Parkinsonism and Related Disorders 21 (8) : 843-847. ScholarBank@NUS Repository. https://doi.org/10.1016/j.parkreldis.2015.04.017
dc.identifier.issn1353-8020
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/149115
dc.description.abstractBackground: Non-motor symptoms (NMS) are common among patients with Parkinson's disease (PD) however little is known about their progression in terms of severity or burden after referral to expert care. Objective: This study was aimed to establish the progression of NMS burden in PD patients after referral to tertiary healthcare centre and factors affecting it. Methods: Newly referred PD patients were prospectively enrolled and follow-up for up to 18 months. Non-motor symptoms scale (NMSS) was used to evaluate the burden of non-motor symptoms. Results: There was a significant median reduction of total NMS burden over the follow-up period. Similarly all NMS domains except domains 2 (sleep/fatigue), 3 (mood/cognition), 6 (gastrointestinal) and 7 (urinary) showed significant median reduction of scores. In the univariate regression analysis, Hoehn & Yahr staging, disease duration, visit, Schwab & England Activities of Daily Living score and UPDRS motor scores were individually predictive of change in total NMS burden. However, in the multivariable regression analysis only the latter three were significantly predictive of change in the total NMS burden. Conclusion: There was a significant reduction of total NMS burden over the study period. The severity of motor and activity of daily living impairments as well as subsequent visit were the best predictors of NMS change. � 2015 Elsevier Ltd.
dc.publisherElsevier Ltd
dc.subjectNon-motor symptoms
dc.subjectParkinson's disease
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1016/j.parkreldis.2015.04.017
dc.description.sourcetitleParkinsonism and Related Disorders
dc.description.volume21
dc.description.issue8
dc.description.page843-847
dc.description.codenPRDIF
dc.published.statepublished
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