Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.scr.2016.12.013
Title: Development of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient carrying the N551K variant in LRRK2 gene
Authors: Ma D. 
Ng E.Y.
Zeng L. 
Lim C.Y.Y.
Zhao Y.
Tan E.K. 
Issue Date: 2017
Publisher: Elsevier B.V.
Citation: Ma D., Ng E.Y., Zeng L., Lim C.Y.Y., Zhao Y., Tan E.K. (2017). Development of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient carrying the N551K variant in LRRK2 gene. Stem Cell Research 18 : 51-53. ScholarBank@NUS Repository. https://doi.org/10.1016/j.scr.2016.12.013
Abstract: Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 64-year old male Parkinson's disease (PD) patient with N551K variant in the LRRK2 gene. The PMBCs were reprogrammed with the human OSKM transcription factors using the Sendai-virus reprogramming system. The transgene-free iPSC showed pluripotency confirmed by immunofluorescent staining for pluripotency markers and differentiated into the 3 germ layers in vivo. The iPSC line also showed normal karyotype. This cellular model can complement in vivo PD models for pathophysiological studies and drug screening. © 2016 The Authors
Source Title: Stem Cell Research
URI: http://scholarbank.nus.edu.sg/handle/10635/148967
ISSN: 18735061
DOI: 10.1016/j.scr.2016.12.013
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