Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.scr.2016.12.013
DC Field | Value | |
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dc.title | Development of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient carrying the N551K variant in LRRK2 gene | |
dc.contributor.author | Ma D. | |
dc.contributor.author | Ng E.Y. | |
dc.contributor.author | Zeng L. | |
dc.contributor.author | Lim C.Y.Y. | |
dc.contributor.author | Zhao Y. | |
dc.contributor.author | Tan E.K. | |
dc.date.accessioned | 2018-11-26T04:03:38Z | |
dc.date.available | 2018-11-26T04:03:38Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Ma D., Ng E.Y., Zeng L., Lim C.Y.Y., Zhao Y., Tan E.K. (2017). Development of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient carrying the N551K variant in LRRK2 gene. Stem Cell Research 18 : 51-53. ScholarBank@NUS Repository. https://doi.org/10.1016/j.scr.2016.12.013 | |
dc.identifier.issn | 18735061 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/148967 | |
dc.description.abstract | Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 64-year old male Parkinson's disease (PD) patient with N551K variant in the LRRK2 gene. The PMBCs were reprogrammed with the human OSKM transcription factors using the Sendai-virus reprogramming system. The transgene-free iPSC showed pluripotency confirmed by immunofluorescent staining for pluripotency markers and differentiated into the 3 germ layers in vivo. The iPSC line also showed normal karyotype. This cellular model can complement in vivo PD models for pathophysiological studies and drug screening. © 2016 The Authors | |
dc.publisher | Elsevier B.V. | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1016/j.scr.2016.12.013 | |
dc.description.sourcetitle | Stem Cell Research | |
dc.description.volume | 18 | |
dc.description.page | 51-53 | |
dc.published.state | published | |
dc.grant.id | NMRC/STaR/014/2013 | |
dc.grant.id | NMRC/TCR/013-NNI/2014 | |
dc.grant.fundingagency | Center for Clinical and Translational Research | |
dc.grant.fundingagency | Center for Clinical and Translational Research | |
Appears in Collections: | Staff Publications Elements |
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