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https://scholarbank.nus.edu.sg/handle/10635/132548
| Title: | Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region | Authors: | Lu, S.-J. Day, N.E. Degos, L. Lepage, V. Wang, P.-C. Chan, S.-H. Simons, M. McKnight, B. Easton, D. Zeng, Y. De-Thé, G. |
Issue Date: | 2-Aug-1990 | Citation: | Lu, S.-J., Day, N.E., Degos, L., Lepage, V., Wang, P.-C., Chan, S.-H., Simons, M., McKnight, B., Easton, D., Zeng, Y., De-Thé, G. (1990-08-02). Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region. Nature 346 (6283) : 470-471. ScholarBank@NUS Repository. | Abstract: | THE frequency of nasopharyngeal carcinoma is nearly 100-fold higher in southern Chinese than in most European populations1. Earlier studies have suggested that an increased risk of nasopharyngeal carcinoma is associated with specific haplotypes in the HLA region: relative risks slightly over twofold were found for haplotypes A2, Bw46 and the antigen B17 (refs 2-4). We now report a linkage study based on affected sib pairs which suggests that a gene closely linked to the HLA locus confers a greatly increased risk of nasopharyngeal carcinoma. The maximum likelihood estimate is of a relative risk of approximately 21. The relationship between this suspected disease susceptibility gene (or genes) and known viral and environmental aetiological factors remains to be elucidated. | Source Title: | Nature | URI: | http://scholarbank.nus.edu.sg/handle/10635/132548 | ISSN: | 00280836 |
| Appears in Collections: | Staff Publications |
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