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|Title:||Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region|
|Citation:||Lu, S.-J., Day, N.E., Degos, L., Lepage, V., Wang, P.-C., Chan, S.-H., Simons, M., McKnight, B., Easton, D., Zeng, Y., De-Thé, G. (1990-08-02). Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region. Nature 346 (6283) : 470-471. ScholarBank@NUS Repository.|
|Abstract:||THE frequency of nasopharyngeal carcinoma is nearly 100-fold higher in southern Chinese than in most European populations1. Earlier studies have suggested that an increased risk of nasopharyngeal carcinoma is associated with specific haplotypes in the HLA region: relative risks slightly over twofold were found for haplotypes A2, Bw46 and the antigen B17 (refs 2-4). We now report a linkage study based on affected sib pairs which suggests that a gene closely linked to the HLA locus confers a greatly increased risk of nasopharyngeal carcinoma. The maximum likelihood estimate is of a relative risk of approximately 21. The relationship between this suspected disease susceptibility gene (or genes) and known viral and environmental aetiological factors remains to be elucidated.|
|Appears in Collections:||Staff Publications|
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