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https://scholarbank.nus.edu.sg/handle/10635/132548
DC Field | Value | |
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dc.title | Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region | |
dc.contributor.author | Lu, S.-J. | |
dc.contributor.author | Day, N.E. | |
dc.contributor.author | Degos, L. | |
dc.contributor.author | Lepage, V. | |
dc.contributor.author | Wang, P.-C. | |
dc.contributor.author | Chan, S.-H. | |
dc.contributor.author | Simons, M. | |
dc.contributor.author | McKnight, B. | |
dc.contributor.author | Easton, D. | |
dc.contributor.author | Zeng, Y. | |
dc.contributor.author | De-Thé, G. | |
dc.date.accessioned | 2016-12-13T05:33:43Z | |
dc.date.available | 2016-12-13T05:33:43Z | |
dc.date.issued | 1990-08-02 | |
dc.identifier.citation | Lu, S.-J., Day, N.E., Degos, L., Lepage, V., Wang, P.-C., Chan, S.-H., Simons, M., McKnight, B., Easton, D., Zeng, Y., De-Thé, G. (1990-08-02). Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region. Nature 346 (6283) : 470-471. ScholarBank@NUS Repository. | |
dc.identifier.issn | 00280836 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/132548 | |
dc.description.abstract | THE frequency of nasopharyngeal carcinoma is nearly 100-fold higher in southern Chinese than in most European populations1. Earlier studies have suggested that an increased risk of nasopharyngeal carcinoma is associated with specific haplotypes in the HLA region: relative risks slightly over twofold were found for haplotypes A2, Bw46 and the antigen B17 (refs 2-4). We now report a linkage study based on affected sib pairs which suggests that a gene closely linked to the HLA locus confers a greatly increased risk of nasopharyngeal carcinoma. The maximum likelihood estimate is of a relative risk of approximately 21. The relationship between this suspected disease susceptibility gene (or genes) and known viral and environmental aetiological factors remains to be elucidated. | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | MICROBIOLOGY | |
dc.description.sourcetitle | Nature | |
dc.description.volume | 346 | |
dc.description.issue | 6283 | |
dc.description.page | 470-471 | |
dc.description.coden | NATUA | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Staff Publications |
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