Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/132548
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dc.titleLinkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region
dc.contributor.authorLu, S.-J.
dc.contributor.authorDay, N.E.
dc.contributor.authorDegos, L.
dc.contributor.authorLepage, V.
dc.contributor.authorWang, P.-C.
dc.contributor.authorChan, S.-H.
dc.contributor.authorSimons, M.
dc.contributor.authorMcKnight, B.
dc.contributor.authorEaston, D.
dc.contributor.authorZeng, Y.
dc.contributor.authorDe-Thé, G.
dc.date.accessioned2016-12-13T05:33:43Z
dc.date.available2016-12-13T05:33:43Z
dc.date.issued1990-08-02
dc.identifier.citationLu, S.-J., Day, N.E., Degos, L., Lepage, V., Wang, P.-C., Chan, S.-H., Simons, M., McKnight, B., Easton, D., Zeng, Y., De-Thé, G. (1990-08-02). Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region. Nature 346 (6283) : 470-471. ScholarBank@NUS Repository.
dc.identifier.issn00280836
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/132548
dc.description.abstractTHE frequency of nasopharyngeal carcinoma is nearly 100-fold higher in southern Chinese than in most European populations1. Earlier studies have suggested that an increased risk of nasopharyngeal carcinoma is associated with specific haplotypes in the HLA region: relative risks slightly over twofold were found for haplotypes A2, Bw46 and the antigen B17 (refs 2-4). We now report a linkage study based on affected sib pairs which suggests that a gene closely linked to the HLA locus confers a greatly increased risk of nasopharyngeal carcinoma. The maximum likelihood estimate is of a relative risk of approximately 21. The relationship between this suspected disease susceptibility gene (or genes) and known viral and environmental aetiological factors remains to be elucidated.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.sourcetitleNature
dc.description.volume346
dc.description.issue6283
dc.description.page470-471
dc.description.codenNATUA
dc.identifier.isiutNOT_IN_WOS
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