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https://doi.org/10.1021/np9700679
| Title: | Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis | Authors: | Hallock, Y.F. Manfredi, K.P. Dai, J.-R. Cardellina II, J.H. Gulakowski, R.J. McMahon, J.B. Schäffer, M. Stahl, M. Gulden, K.-P. Bringmann, G. François, G. Boyd, M.R. |
Issue Date: | Jul-1997 | Citation: | Hallock, Y.F., Manfredi, K.P., Dai, J.-R., Cardellina II, J.H., Gulakowski, R.J., McMahon, J.B., Schäffer, M., Stahl, M., Gulden, K.-P., Bringmann, G., François, G., Boyd, M.R. (1997-07). Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis. Journal of Natural Products 60 (7) : 677-683. ScholarBank@NUS Repository. https://doi.org/10.1021/np9700679 | Abstract: | New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D. | Source Title: | Journal of Natural Products | URI: | http://scholarbank.nus.edu.sg/handle/10635/131478 | ISSN: | 01633864 | DOI: | 10.1021/np9700679 |
| Appears in Collections: | Staff Publications |
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