Please use this identifier to cite or link to this item: https://doi.org/10.1021/np9700679
Title: Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis
Authors: Hallock, Y.F.
Manfredi, K.P.
Dai, J.-R. 
Cardellina II, J.H.
Gulakowski, R.J.
McMahon, J.B.
Schäffer, M.
Stahl, M.
Gulden, K.-P.
Bringmann, G.
François, G.
Boyd, M.R.
Issue Date: Jul-1997
Source: Hallock, Y.F., Manfredi, K.P., Dai, J.-R., Cardellina II, J.H., Gulakowski, R.J., McMahon, J.B., Schäffer, M., Stahl, M., Gulden, K.-P., Bringmann, G., François, G., Boyd, M.R. (1997-07). Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis. Journal of Natural Products 60 (7) : 677-683. ScholarBank@NUS Repository. https://doi.org/10.1021/np9700679
Abstract: New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D.
Source Title: Journal of Natural Products
URI: http://scholarbank.nus.edu.sg/handle/10635/131478
ISSN: 01633864
DOI: 10.1021/np9700679
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