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https://doi.org/10.1016/j.neurobiolaging.2007.07.010
| Title: | Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease | Authors: | Tan, E.K. Lee, J. Chen, C.P. Wong, M.C. Zhao, Y. |
Keywords: | Alzheimer's disease Gene Variant |
Issue Date: | Mar-2009 | Citation: | Tan, E.K., Lee, J., Chen, C.P., Wong, M.C., Zhao, Y. (2009-03). Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease. Neurobiology of Aging 30 (3) : 501-502. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2007.07.010 | Abstract: | Alzheimer's disease (AD) pathology has been described in Parkinson's disease (PD) patients with leucine-rich repeat kinase-2 (LRRK2) mutations. A common LRRK2 Gly2385Arg variant has been widely shown to be associated with a twofold increased risk of PD in various Asian populations. In a case control study, the frequency of the heterozygous Gly2385Arg genotype was demonstrated in 4.3% of AD compared to 4.5% in controls (odds ratio = 0.94, 95% CI 0.37-2.42, p = 1.0). The Gly2385Arg variant does not appear to modulate the risk of AD in our population. © 2007 Elsevier Inc. All rights reserved. | Source Title: | Neurobiology of Aging | URI: | http://scholarbank.nus.edu.sg/handle/10635/129480 | ISSN: | 01974580 | DOI: | 10.1016/j.neurobiolaging.2007.07.010 |
| Appears in Collections: | Staff Publications |
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