Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neurobiolaging.2007.07.010
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dc.titleCase control analysis of LRRK2 Gly2385Arg in Alzheimer's disease
dc.contributor.authorTan, E.K.
dc.contributor.authorLee, J.
dc.contributor.authorChen, C.P.
dc.contributor.authorWong, M.C.
dc.contributor.authorZhao, Y.
dc.date.accessioned2016-11-08T08:23:04Z
dc.date.available2016-11-08T08:23:04Z
dc.date.issued2009-03
dc.identifier.citationTan, E.K., Lee, J., Chen, C.P., Wong, M.C., Zhao, Y. (2009-03). Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease. Neurobiology of Aging 30 (3) : 501-502. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neurobiolaging.2007.07.010
dc.identifier.issn01974580
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/129480
dc.description.abstractAlzheimer's disease (AD) pathology has been described in Parkinson's disease (PD) patients with leucine-rich repeat kinase-2 (LRRK2) mutations. A common LRRK2 Gly2385Arg variant has been widely shown to be associated with a twofold increased risk of PD in various Asian populations. In a case control study, the frequency of the heterozygous Gly2385Arg genotype was demonstrated in 4.3% of AD compared to 4.5% in controls (odds ratio = 0.94, 95% CI 0.37-2.42, p = 1.0). The Gly2385Arg variant does not appear to modulate the risk of AD in our population. © 2007 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.neurobiolaging.2007.07.010
dc.sourceScopus
dc.subjectAlzheimer's disease
dc.subjectGene
dc.subjectVariant
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.1016/j.neurobiolaging.2007.07.010
dc.description.sourcetitleNeurobiology of Aging
dc.description.volume30
dc.description.issue3
dc.description.page501-502
dc.description.codenNEAGD
dc.identifier.isiut000263154700017
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