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Title: Six cases of daptomycin-non-susceptible Staphylococcus aureus bacteraemia in Singapore
Authors: Hsu, L.-Y. 
Leong, M.
Balm, M. 
Chan, D.S.
Huggan, P. 
Tan, T.-Y.
Koh, T.-H.
Hon, P.-Y.
Ng, M.M. 
Issue Date: Dec-2010
Citation: Hsu, L.-Y., Leong, M., Balm, M., Chan, D.S., Huggan, P., Tan, T.-Y., Koh, T.-H., Hon, P.-Y., Ng, M.M. (2010-12). Six cases of daptomycin-non-susceptible Staphylococcus aureus bacteraemia in Singapore. Journal of Medical Microbiology 59 (12) : 1509-1513. ScholarBank@NUS Repository.
Abstract: We report what we believe to be the first six cases of daptomycin-non- susceptible Staphylococcus aureus infections from Singapore. These strains were rapidly isolated after bacteraemic patients were switched to daptomycin following initial prolonged unsuccessful therapy with vancomycin, despite confirmation of daptomycin susceptibility just prior to initiating daptomycin therapy. The majority of post-vancomycin therapy strains exhibited marked thickening of their cell walls on electron microscopic examination. In patients with persistent S. aureus bacteraemia, therapeutic failure with daptomycin may occur if used as salvage therapy following vancomycin failure, notwithstanding initial susceptibility testing results. © 2010 SGM.
Source Title: Journal of Medical Microbiology
ISSN: 00222615
DOI: 10.1099/jmm.0.022533-0
Appears in Collections:Staff Publications

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