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Title: Malignant ovarian germ-cell tumours
Authors: Low, J.J.H. 
Ilancheran, A. 
Ng, J.S.
Keywords: BEP chemotherapy
fertility preservation
malignant ovarian germ-cell tumour
menstrual function
ovarian function
Issue Date: Jun-2012
Citation: Low, J.J.H., Ilancheran, A., Ng, J.S. (2012-06). Malignant ovarian germ-cell tumours. Best Practice and Research: Clinical Obstetrics and Gynaecology 26 (3) : 347-355. ScholarBank@NUS Repository.
Abstract: Malignant ovarian germ-cell tumours account for about 5% of all ovarian malignancies and typically present in the teenage years. They are almost always unilateral and are exquisitely chemosensitive. As such, the surgical approach in young women with such tumours confined to a single ovary should aim to preserve fertility. In early disease, a unilateral salpingo-oophorectomy with careful surgical staging is of great importance in selecting appropriate adjuvant therapy. In advanced disease, the role of aggressive cytoreducation is not well defined, and removal of both ovaries does not confer improvement in outcome. Bleomycin, etoposide and cisplatin combination chemotherapy is regarded as the gold standard for adjuvant therapy. Studies evaluating ovarian and reproductive capacity after conservative surgery and chemotherapy for malignant ovarian germ-cell tumours have consistently demonstrated excellent prognosis, with the return of normal menstrual function and fertility rates in these women with no increase in the risk of teratogenicity. © 2012 Elsevier Ltd. All rights reserved.
Source Title: Best Practice and Research: Clinical Obstetrics and Gynaecology
ISSN: 15216934
DOI: 10.1016/j.bpobgyn.2012.01.002
Appears in Collections:Staff Publications

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