Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bpobgyn.2012.01.002
Title: Malignant ovarian germ-cell tumours
Authors: Low, J.J.H. 
Ilancheran, A. 
Ng, J.S.
Keywords: BEP chemotherapy
fertility preservation
malignant ovarian germ-cell tumour
menstrual function
ovarian function
Issue Date: Jun-2012
Source: Low, J.J.H., Ilancheran, A., Ng, J.S. (2012-06). Malignant ovarian germ-cell tumours. Best Practice and Research: Clinical Obstetrics and Gynaecology 26 (3) : 347-355. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bpobgyn.2012.01.002
Abstract: Malignant ovarian germ-cell tumours account for about 5% of all ovarian malignancies and typically present in the teenage years. They are almost always unilateral and are exquisitely chemosensitive. As such, the surgical approach in young women with such tumours confined to a single ovary should aim to preserve fertility. In early disease, a unilateral salpingo-oophorectomy with careful surgical staging is of great importance in selecting appropriate adjuvant therapy. In advanced disease, the role of aggressive cytoreducation is not well defined, and removal of both ovaries does not confer improvement in outcome. Bleomycin, etoposide and cisplatin combination chemotherapy is regarded as the gold standard for adjuvant therapy. Studies evaluating ovarian and reproductive capacity after conservative surgery and chemotherapy for malignant ovarian germ-cell tumours have consistently demonstrated excellent prognosis, with the return of normal menstrual function and fertility rates in these women with no increase in the risk of teratogenicity. © 2012 Elsevier Ltd. All rights reserved.
Source Title: Best Practice and Research: Clinical Obstetrics and Gynaecology
URI: http://scholarbank.nus.edu.sg/handle/10635/127003
ISSN: 15216934
DOI: 10.1016/j.bpobgyn.2012.01.002
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

31
checked on Feb 14, 2018

WEB OF SCIENCETM
Citations

22
checked on Jan 24, 2018

Page view(s)

11
checked on Feb 19, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.