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Title: Targeted ANP32E Mutant Mice Do Not Demonstrate Obvious Movement Defects
Authors: Wong, P. 
Leo, V.I.
Low, M.
Mak, T.W.
Zhang, X. 
Reilly, P.T.
Issue Date: 13-May-2013
Citation: Wong, P., Leo, V.I., Low, M., Mak, T.W., Zhang, X., Reilly, P.T. (2013-05-13). Targeted ANP32E Mutant Mice Do Not Demonstrate Obvious Movement Defects. PLoS ONE 8 (5) : -. ScholarBank@NUS Repository.
Abstract: Background:The ANP32 family of proteins have been implicated in neuronal function through biochemical and cellular biology studies in neurons, as well as by recent behavioural studies of a gene-trapped loss-of-function mutation of Anp32e in mice, particularly with respect to fine motor function. A second targeted allele of the Anp32e, however, did not appear to demonstrate neurological phenotypes.Methodology/Principal Findings:Using a stringently controlled cohort of ten-generation backcrossed, co-caged, sex-matched, littermate pairs, we assayed for potential motor defects in the targeted ANP32E-deficient mice. We found no phenotypic difference in any assays.Conclusion:Since it is unlikely that the gene-trap is a more complete loss-of-function, our results suggest that ANP32E has no appreciable effect on motor functions and that genetic background differences most likely account for the gene-trap phenomena. © 2013 Wong et al.
Source Title: PLoS ONE
ISSN: 19326203
DOI: 10.1371/journal.pone.0063815
Appears in Collections:Staff Publications

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