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|Title:||Targeted ANP32E Mutant Mice Do Not Demonstrate Obvious Movement Defects|
|Authors:||Wong, P. |
|Source:||Wong, P., Leo, V.I., Low, M., Mak, T.W., Zhang, X., Reilly, P.T. (2013-05-13). Targeted ANP32E Mutant Mice Do Not Demonstrate Obvious Movement Defects. PLoS ONE 8 (5) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0063815|
|Abstract:||Background:The ANP32 family of proteins have been implicated in neuronal function through biochemical and cellular biology studies in neurons, as well as by recent behavioural studies of a gene-trapped loss-of-function mutation of Anp32e in mice, particularly with respect to fine motor function. A second targeted allele of the Anp32e, however, did not appear to demonstrate neurological phenotypes.Methodology/Principal Findings:Using a stringently controlled cohort of ten-generation backcrossed, co-caged, sex-matched, littermate pairs, we assayed for potential motor defects in the targeted ANP32E-deficient mice. We found no phenotypic difference in any assays.Conclusion:Since it is unlikely that the gene-trap is a more complete loss-of-function, our results suggest that ANP32E has no appreciable effect on motor functions and that genetic background differences most likely account for the gene-trap phenomena. © 2013 Wong et al.|
|Source Title:||PLoS ONE|
|Appears in Collections:||Staff Publications|
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