Please use this identifier to cite or link to this item:
|Title:||Hepatocellular carcinoma: Transcriptome diversity regulated by RNA editing||Authors:||Li, Y.
|Keywords:||A-to-I RNA editing
|Issue Date:||2013||Citation:||Li, Y., Chen, L., Chan, T.H.M., Guana, X.-Y. (2013). Hepatocellular carcinoma: Transcriptome diversity regulated by RNA editing. International Journal of Biochemistry and Cell Biology 45 (8) : 1843-1848. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biocel.2013.05.033||Abstract:||Hepatocellular carcinoma (HCC) can be envisioned as a prolonged multi-stage process accumulating genetic and epigenetic changes. In the past years, DNA alterations lent us important clues to the com-prehension of molecular pathways involved in HCC. However, as an increasing number of RNAs were identified to be subject to A-to-I modifications, it has become apparent that RNA editing might be the causal basis of various human diseases. Recent evidence has strengthened this notion by correlating hyper-edited AZIN1 (antizyme inhibitor 1) protein with HCC onset and the mechanisms that regulate cell transformation. As we continue to demystify it, RNA editing astonishes us with its diverse substrates, esoteric functions, elaborate machinery and complex interaction with HBV/HCV viral infection. In this review, we examine the contribution of A-to-I RNA editing to caner onset/progression and explore its potential implications for cancer treatment advances. © 2013 Elsevier Ltd. All rights reserved.||Source Title:||International Journal of Biochemistry and Cell Biology||URI:||http://scholarbank.nus.edu.sg/handle/10635/126285||ISSN:||13572725||DOI:||10.1016/j.biocel.2013.05.033|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 5, 2020
WEB OF SCIENCETM
checked on Jul 28, 2020
checked on Jul 31, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.