Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biocel.2013.05.033
DC FieldValue
dc.titleHepatocellular carcinoma: Transcriptome diversity regulated by RNA editing
dc.contributor.authorLi, Y.
dc.contributor.authorChen, L.
dc.contributor.authorChan, T.H.M.
dc.contributor.authorGuana, X.-Y.
dc.date.accessioned2016-09-01T07:17:08Z
dc.date.available2016-09-01T07:17:08Z
dc.date.issued2013
dc.identifier.citationLi, Y., Chen, L., Chan, T.H.M., Guana, X.-Y. (2013). Hepatocellular carcinoma: Transcriptome diversity regulated by RNA editing. International Journal of Biochemistry and Cell Biology 45 (8) : 1843-1848. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biocel.2013.05.033
dc.identifier.issn13572725
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/126285
dc.description.abstractHepatocellular carcinoma (HCC) can be envisioned as a prolonged multi-stage process accumulating genetic and epigenetic changes. In the past years, DNA alterations lent us important clues to the com-prehension of molecular pathways involved in HCC. However, as an increasing number of RNAs were identified to be subject to A-to-I modifications, it has become apparent that RNA editing might be the causal basis of various human diseases. Recent evidence has strengthened this notion by correlating hyper-edited AZIN1 (antizyme inhibitor 1) protein with HCC onset and the mechanisms that regulate cell transformation. As we continue to demystify it, RNA editing astonishes us with its diverse substrates, esoteric functions, elaborate machinery and complex interaction with HBV/HCV viral infection. In this review, we examine the contribution of A-to-I RNA editing to caner onset/progression and explore its potential implications for cancer treatment advances. © 2013 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biocel.2013.05.033
dc.sourceScopus
dc.subjectA-to-I RNA editing
dc.subjectADARs
dc.subjectAZIN1
dc.subjectHCC
dc.subjectTranscriptome
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1016/j.biocel.2013.05.033
dc.description.sourcetitleInternational Journal of Biochemistry and Cell Biology
dc.description.volume45
dc.description.issue8
dc.description.page1843-1848
dc.description.codenIJBBF
dc.identifier.isiut000322925200035
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Sep 24, 2020

WEB OF SCIENCETM
Citations

12
checked on Sep 17, 2020

Page view(s)

52
checked on Sep 26, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.