Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biocel.2013.05.033
Title: Hepatocellular carcinoma: Transcriptome diversity regulated by RNA editing
Authors: Li, Y.
Chen, L. 
Chan, T.H.M.
Guana, X.-Y.
Keywords: A-to-I RNA editing
ADARs
AZIN1
HCC
Transcriptome
Issue Date: 2013
Citation: Li, Y., Chen, L., Chan, T.H.M., Guana, X.-Y. (2013). Hepatocellular carcinoma: Transcriptome diversity regulated by RNA editing. International Journal of Biochemistry and Cell Biology 45 (8) : 1843-1848. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biocel.2013.05.033
Abstract: Hepatocellular carcinoma (HCC) can be envisioned as a prolonged multi-stage process accumulating genetic and epigenetic changes. In the past years, DNA alterations lent us important clues to the com-prehension of molecular pathways involved in HCC. However, as an increasing number of RNAs were identified to be subject to A-to-I modifications, it has become apparent that RNA editing might be the causal basis of various human diseases. Recent evidence has strengthened this notion by correlating hyper-edited AZIN1 (antizyme inhibitor 1) protein with HCC onset and the mechanisms that regulate cell transformation. As we continue to demystify it, RNA editing astonishes us with its diverse substrates, esoteric functions, elaborate machinery and complex interaction with HBV/HCV viral infection. In this review, we examine the contribution of A-to-I RNA editing to caner onset/progression and explore its potential implications for cancer treatment advances. © 2013 Elsevier Ltd. All rights reserved.
Source Title: International Journal of Biochemistry and Cell Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/126285
ISSN: 13572725
DOI: 10.1016/j.biocel.2013.05.033
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