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Title: Long-chain polyunsaturated fatty acid status during pregnancy and maternal mental health in pregnancy and the postpartum period: Results from the GUSTO study
Authors: Chong, Foong Foong Mary 
Ong, Yi Lin
Calder, Philip C.
Colega, Marjorelee
Wong, X.Y. Jocelyn
Tan, Chuen Seng 
Lim, Ai Lin
Fisk, L. Helena
Cai, Shi Rong 
Pang, Wei Wei 
Broekman, Birit F.P. 
Saw, Seang Mei 
Kwek, Yung Chiang Kenneth 
Godfrey, Keith M
Chong, Yap Seng 
Gluckman, Peter D. 
Meaney, Michael Joseph
Chen, Yu Helen 
Issue Date: 1-Jul-2015
Publisher: Physicians Postgraduate Press
Citation: Chong, Foong Foong Mary, Ong, Yi Lin, Calder, Philip C., Colega, Marjorelee, Wong, X.Y. Jocelyn, Tan, Chuen Seng, Lim, Ai Lin, Fisk, L. Helena, Cai, Shi Rong, Pang, Wei Wei, Broekman, Birit F.P., Saw, Seang Mei, Kwek, Yung Chiang Kenneth, Godfrey, Keith M, Chong, Yap Seng, Gluckman, Peter D., Meaney, Michael Joseph, Chen, Yu Helen (2015-07-01). Long-chain polyunsaturated fatty acid status during pregnancy and maternal mental health in pregnancy and the postpartum period: Results from the GUSTO study. Journal of Clinical Psychiatry 76 (7) : e848-e856. ScholarBank@NUS Repository.
Abstract: Objective: Studies have demonstrated a relationship between lower omega-3 long-chain polyunsaturated fatty acid (LC-PUFA) status and anxiety and depression. It is uncertain whether similar associations occur in pregnant women, when anxiety and depression could have long-term effects on the offspring. We examined the associations between plasma LC-PUFA status during pregnancy and perinatal mental health. Method: At 26-28 weeks gestation, plasma LC-PUFAs were measured in mothers of the Growing Up in Singapore Toward healthy Outcomes (GUSTO) mother-offspring cohort study, who were recruited between June 2009 and September 2010. Maternal symptoms of anxiety and depression were assessed with the State-Trait Anxiety Inventory (STAI) and Edinburgh Postnatal Depression Scale (EPDS) during the same period and at 3 months postpartum. The STAI-state subscale was used as a continuous measure of current anxiety, while EPDS scores ≥ 15 during pregnancy or ≥ 13 postpartum were indicative of symptoms of probable depression. Results: In adjusted regression analyses (n = 698), lower plasma total omega-3 PUFA concentrations (β =.6.49 STAI-state subscale scores/unit increase of omega-3 fatty acid; 95% CI,.11.90 to.1.08) and higher plasma omega-6:omega-3 PUFA ratios (β = 6.58 scores/unit increase of fatty acid ratio; 95% CI, 1.19 to 12.66), specifically higher arachidonic acid (AA):docosahexaenoic acid, AA:eicosapentaenoic acid, and AA:docosapentaenoic acid ratios, were associated with increased antenatal anxiety (P.05 for all), but not postpartum anxiety. There was no association between plasma PUFAs and perinatal probable depression. Conclusions: No association was found with probable depression in pregnancy or postpartum. Lower plasma omega-3 fatty acids and higher omega-6:omega-3 fatty acid ratios were associated with higher antenatal anxiety, but not postpartum anxiety. Replication in other studies is needed to confirm the findings and determine the direction of causality. © 2015 Physicians Postgraduate Press, Inc.
Source Title: Journal of Clinical Psychiatry
ISSN: 01606689
DOI: 10.4088/JCP.14m09191
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