Please use this identifier to cite or link to this item: https://doi.org/10.4088/JCP.14m09191
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dc.titleLong-chain polyunsaturated fatty acid status during pregnancy and maternal mental health in pregnancy and the postpartum period: Results from the GUSTO study
dc.contributor.authorChong, Foong Foong Mary
dc.contributor.authorOng, Yi Lin
dc.contributor.authorCalder, Philip C.
dc.contributor.authorColega, Marjorelee
dc.contributor.authorWong, X.Y. Jocelyn
dc.contributor.authorTan, Chuen Seng
dc.contributor.authorLim, Ai Lin
dc.contributor.authorFisk, L. Helena
dc.contributor.authorCai, Shi Rong
dc.contributor.authorPang, Wei Wei
dc.contributor.authorBroekman, Birit F.P.
dc.contributor.authorSaw, Seang Mei
dc.contributor.authorKwek, Yung Chiang Kenneth
dc.contributor.authorGodfrey, Keith M
dc.contributor.authorChong, Yap Seng
dc.contributor.authorGluckman, Peter D.
dc.contributor.authorMeaney, Michael Joseph
dc.contributor.authorChen, Yu Helen
dc.date.accessioned2015-09-28T05:57:42Z
dc.date.available2015-09-28T05:57:42Z
dc.date.issued2015-07-01
dc.identifier.citationChong, Foong Foong Mary, Ong, Yi Lin, Calder, Philip C., Colega, Marjorelee, Wong, X.Y. Jocelyn, Tan, Chuen Seng, Lim, Ai Lin, Fisk, L. Helena, Cai, Shi Rong, Pang, Wei Wei, Broekman, Birit F.P., Saw, Seang Mei, Kwek, Yung Chiang Kenneth, Godfrey, Keith M, Chong, Yap Seng, Gluckman, Peter D., Meaney, Michael Joseph, Chen, Yu Helen (2015-07-01). Long-chain polyunsaturated fatty acid status during pregnancy and maternal mental health in pregnancy and the postpartum period: Results from the GUSTO study. Journal of Clinical Psychiatry 76 (7) : e848-e856. ScholarBank@NUS Repository. https://doi.org/10.4088/JCP.14m09191
dc.identifier.issn01606689
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/121060
dc.description.abstractObjective: Studies have demonstrated a relationship between lower omega-3 long-chain polyunsaturated fatty acid (LC-PUFA) status and anxiety and depression. It is uncertain whether similar associations occur in pregnant women, when anxiety and depression could have long-term effects on the offspring. We examined the associations between plasma LC-PUFA status during pregnancy and perinatal mental health. Method: At 26-28 weeks gestation, plasma LC-PUFAs were measured in mothers of the Growing Up in Singapore Toward healthy Outcomes (GUSTO) mother-offspring cohort study, who were recruited between June 2009 and September 2010. Maternal symptoms of anxiety and depression were assessed with the State-Trait Anxiety Inventory (STAI) and Edinburgh Postnatal Depression Scale (EPDS) during the same period and at 3 months postpartum. The STAI-state subscale was used as a continuous measure of current anxiety, while EPDS scores ≥ 15 during pregnancy or ≥ 13 postpartum were indicative of symptoms of probable depression. Results: In adjusted regression analyses (n = 698), lower plasma total omega-3 PUFA concentrations (β =.6.49 STAI-state subscale scores/unit increase of omega-3 fatty acid; 95% CI,.11.90 to.1.08) and higher plasma omega-6:omega-3 PUFA ratios (β = 6.58 scores/unit increase of fatty acid ratio; 95% CI, 1.19 to 12.66), specifically higher arachidonic acid (AA):docosahexaenoic acid, AA:eicosapentaenoic acid, and AA:docosapentaenoic acid ratios, were associated with increased antenatal anxiety (P.05 for all), but not postpartum anxiety. There was no association between plasma PUFAs and perinatal probable depression. Conclusions: No association was found with probable depression in pregnancy or postpartum. Lower plasma omega-3 fatty acids and higher omega-6:omega-3 fatty acid ratios were associated with higher antenatal anxiety, but not postpartum anxiety. Replication in other studies is needed to confirm the findings and determine the direction of causality. © 2015 Physicians Postgraduate Press, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.4088/JCP.14m09191
dc.publisherPhysicians Postgraduate Press
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.contributor.departmentOBSTETRICS & GYNAECOLOGY
dc.contributor.departmentPSYCHOLOGICAL MEDICINE
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.4088/JCP.14m09191
dc.description.sourcetitleJournal of Clinical Psychiatry
dc.description.volume76
dc.description.issue7
dc.description.pagee848-e856
dc.identifier.isiut000361535200002
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
dc.published.statePublished
dc.grant.idNMRC/TCR/004-NUS/2008
dc.grant.idNMRC/TCR/012-NUHS/2014
dc.grant.fundingagencyNational Medical Research Council (Singapore)
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