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https://doi.org/10.1158/0008-5472.CAN-06-1464
Title: | Heparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective | Authors: | Götte, M. Yip, G.W. |
Issue Date: | 1-Nov-2006 | Citation: | Götte, M., Yip, G.W. (2006-11-01). Heparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective. Cancer Research 66 (21) : 10233-10237. ScholarBank@NUS Repository. https://doi.org/10.1158/0008-5472.CAN-06-1464 | Abstract: | Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma. The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are up-regulated in breast cancer, generating a microenvironment that promotes tumor progression and metastasis. Recent experimental and clinical evidence shows that heparanase, hyaluronan, and CD44 regulate cancer cell proliferation, migration, and invasion, as well as tumor-associated angiogenesis and are correlated with patient survival. These findings suggest that they may be used as prognostic factors and targets for breast cancer treatment. ©2006 American Association for Cancer Research. | Source Title: | Cancer Research | URI: | http://scholarbank.nus.edu.sg/handle/10635/120695 | ISSN: | 00085472 | DOI: | 10.1158/0008-5472.CAN-06-1464 |
Appears in Collections: | Staff Publications |
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