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Title: Heparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective
Authors: Götte, M.
Yip, G.W. 
Issue Date: 1-Nov-2006
Citation: Götte, M., Yip, G.W. (2006-11-01). Heparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective. Cancer Research 66 (21) : 10233-10237. ScholarBank@NUS Repository.
Abstract: Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma. The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are up-regulated in breast cancer, generating a microenvironment that promotes tumor progression and metastasis. Recent experimental and clinical evidence shows that heparanase, hyaluronan, and CD44 regulate cancer cell proliferation, migration, and invasion, as well as tumor-associated angiogenesis and are correlated with patient survival. These findings suggest that they may be used as prognostic factors and targets for breast cancer treatment. ©2006 American Association for Cancer Research.
Source Title: Cancer Research
ISSN: 00085472
DOI: 10.1158/0008-5472.CAN-06-1464
Appears in Collections:Staff Publications

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