Please use this identifier to cite or link to this item: https://doi.org/10.1158/0008-5472.CAN-06-1464
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dc.titleHeparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective
dc.contributor.authorGötte, M.
dc.contributor.authorYip, G.W.
dc.date.accessioned2015-09-07T09:55:47Z
dc.date.available2015-09-07T09:55:47Z
dc.date.issued2006-11-01
dc.identifier.citationGötte, M., Yip, G.W. (2006-11-01). Heparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective. Cancer Research 66 (21) : 10233-10237. ScholarBank@NUS Repository. https://doi.org/10.1158/0008-5472.CAN-06-1464
dc.identifier.issn00085472
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/120695
dc.description.abstractGlycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma. The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are up-regulated in breast cancer, generating a microenvironment that promotes tumor progression and metastasis. Recent experimental and clinical evidence shows that heparanase, hyaluronan, and CD44 regulate cancer cell proliferation, migration, and invasion, as well as tumor-associated angiogenesis and are correlated with patient survival. These findings suggest that they may be used as prognostic factors and targets for breast cancer treatment. ©2006 American Association for Cancer Research.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1158/0008-5472.CAN-06-1464
dc.sourceScopus
dc.typeReview
dc.contributor.departmentANATOMY
dc.description.doi10.1158/0008-5472.CAN-06-1464
dc.description.sourcetitleCancer Research
dc.description.volume66
dc.description.issue21
dc.description.page10233-10237
dc.description.codenCNREA
dc.identifier.isiut000241781600002
Appears in Collections:Staff Publications

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