Heparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective
Götte, M. Yip, G.W.
Götte, M.
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Abstract
Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma. The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are up-regulated in breast cancer, generating a microenvironment that promotes tumor progression and metastasis. Recent experimental and clinical evidence shows that heparanase, hyaluronan, and CD44 regulate cancer cell proliferation, migration, and invasion, as well as tumor-associated angiogenesis and are correlated with patient survival. These findings suggest that they may be used as prognostic factors and targets for breast cancer treatment. ©2006 American Association for Cancer Research.
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Source Title
Cancer Research
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Series/Report No.
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Date
2006-11-01
DOI
10.1158/0008-5472.CAN-06-1464
Type
Review