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Title: Function of sirtuins in biological tissues
Authors: Shoba, B.
Lwin, Z.M. 
Ling, L.S. 
Bay, B.-H. 
Yip, G.W. 
Kumar, S.D. 
Keywords: Human
Issue Date: 2009
Citation: Shoba, B., Lwin, Z.M., Ling, L.S., Bay, B.-H., Yip, G.W., Kumar, S.D. (2009). Function of sirtuins in biological tissues. Anatomical Record 292 (4) : 536-543. ScholarBank@NUS Repository.
Abstract: Sirtuins are protein deacetylases, which are dependent on nicotine adenine dinucleotide. They are phylogenetically conserved from bacteria to humans. Seven sirtuin proteins localized in a wide variety of subcellular locations have been identified in the human genome. The most important known function of sirtuins is their regulation of transcriptional repression, mediated through binding of a complex containing sirtuins and other proteins. Studies have shown that sirtuins have pathophysiological relevance to neurodegeneration, muscle differentiation, inflammation, obesity, and cancer. In addition, sirtuin activity extends the lifespan of several organisms. In this review, we discuss the mode(s) of action of sirtuins, and their biological role(s) in health and disease. © 2009 Wiley-Liss, Inc.
Source Title: Anatomical Record
ISSN: 19328486
DOI: 10.1002/ar.20875
Appears in Collections:Staff Publications

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