Please use this identifier to cite or link to this item: https://doi.org/10.1002/ar.20875
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dc.titleFunction of sirtuins in biological tissues
dc.contributor.authorShoba, B.
dc.contributor.authorLwin, Z.M.
dc.contributor.authorLing, L.S.
dc.contributor.authorBay, B.-H.
dc.contributor.authorYip, G.W.
dc.contributor.authorKumar, S.D.
dc.date.accessioned2015-09-07T09:55:46Z
dc.date.available2015-09-07T09:55:46Z
dc.date.issued2009
dc.identifier.citationShoba, B., Lwin, Z.M., Ling, L.S., Bay, B.-H., Yip, G.W., Kumar, S.D. (2009). Function of sirtuins in biological tissues. Anatomical Record 292 (4) : 536-543. ScholarBank@NUS Repository. https://doi.org/10.1002/ar.20875
dc.identifier.issn19328486
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/120694
dc.description.abstractSirtuins are protein deacetylases, which are dependent on nicotine adenine dinucleotide. They are phylogenetically conserved from bacteria to humans. Seven sirtuin proteins localized in a wide variety of subcellular locations have been identified in the human genome. The most important known function of sirtuins is their regulation of transcriptional repression, mediated through binding of a complex containing sirtuins and other proteins. Studies have shown that sirtuins have pathophysiological relevance to neurodegeneration, muscle differentiation, inflammation, obesity, and cancer. In addition, sirtuin activity extends the lifespan of several organisms. In this review, we discuss the mode(s) of action of sirtuins, and their biological role(s) in health and disease. © 2009 Wiley-Liss, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/ar.20875
dc.sourceScopus
dc.subjectHuman
dc.subjectProtein
dc.subjectSirtuins
dc.typeReview
dc.contributor.departmentANATOMY
dc.description.doi10.1002/ar.20875
dc.description.sourcetitleAnatomical Record
dc.description.volume292
dc.description.issue4
dc.description.page536-543
dc.identifier.isiut000264998900009
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