Please use this identifier to cite or link to this item:
|Title:||Stem cell exhaustion and leukemogenesis||Authors:||Jacob, B.
Hematopoietic stem cell
|Issue Date:||1-Jun-2009||Citation:||Jacob, B., Osato, M. (2009-06-01). Stem cell exhaustion and leukemogenesis. Journal of Cellular Biochemistry 107 (3) : 393-399. ScholarBank@NUS Repository. https://doi.org/10.1002/jcb.22150||Abstract:||Cancer is the result of a combination of genetic alterations, which aid transformation of cells. However, oncogenic alterations also simultaneously induce some detrimental effects on the cells such as apoptosis, senescence, and differentiation. Such negative effects caused by certain oncogenic events are overcome by other cooperating genetic hits. We propose stem cell exhaustion as a novel detrimental effect that is caused by a wide variety of oncogenic alterations. Interestingly, in most cases, the stem cell exhaustion due to oncogenic alterations is preceded by an abnormal expansion of stem/progenitor cells. This preceding stem/progenitor cell expansion may be a key feature that still promotes cancer development, along with cooperating hits that rescue stem cell exhaustion. This review summarizes current knowledge about hematopoietic stem cell exhaustion and the mechanisms to overcome stem cell exhaustion in cancer development. © 2009 Wiley-Liss, Inc.||Source Title:||Journal of Cellular Biochemistry||URI:||http://scholarbank.nus.edu.sg/handle/10635/116178||ISSN:||07302312||DOI:||10.1002/jcb.22150|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 1, 2021
WEB OF SCIENCETM
checked on Feb 22, 2021
checked on Feb 27, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.