Please use this identifier to cite or link to this item: https://doi.org/10.1002/jcb.22150
DC FieldValue
dc.titleStem cell exhaustion and leukemogenesis
dc.contributor.authorJacob, B.
dc.contributor.authorOsato, M.
dc.date.accessioned2014-12-12T07:37:15Z
dc.date.available2014-12-12T07:37:15Z
dc.date.issued2009-06-01
dc.identifier.citationJacob, B., Osato, M. (2009-06-01). Stem cell exhaustion and leukemogenesis. Journal of Cellular Biochemistry 107 (3) : 393-399. ScholarBank@NUS Repository. https://doi.org/10.1002/jcb.22150
dc.identifier.issn07302312
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/116178
dc.description.abstractCancer is the result of a combination of genetic alterations, which aid transformation of cells. However, oncogenic alterations also simultaneously induce some detrimental effects on the cells such as apoptosis, senescence, and differentiation. Such negative effects caused by certain oncogenic events are overcome by other cooperating genetic hits. We propose stem cell exhaustion as a novel detrimental effect that is caused by a wide variety of oncogenic alterations. Interestingly, in most cases, the stem cell exhaustion due to oncogenic alterations is preceded by an abnormal expansion of stem/progenitor cells. This preceding stem/progenitor cell expansion may be a key feature that still promotes cancer development, along with cooperating hits that rescue stem cell exhaustion. This review summarizes current knowledge about hematopoietic stem cell exhaustion and the mechanisms to overcome stem cell exhaustion in cancer development. © 2009 Wiley-Liss, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jcb.22150
dc.sourceScopus
dc.subjectAML1
dc.subjectHematopoietic stem cell
dc.subjectNiche
dc.subjectRunx1
dc.typeReview
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1002/jcb.22150
dc.description.sourcetitleJournal of Cellular Biochemistry
dc.description.volume107
dc.description.issue3
dc.description.page393-399
dc.description.codenJCEBD
dc.identifier.isiut000266872300003
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