Please use this identifier to cite or link to this item: https://doi.org/10.1002/jcb.22150
Title: Stem cell exhaustion and leukemogenesis
Authors: Jacob, B.
Osato, M. 
Keywords: AML1
Hematopoietic stem cell
Niche
Runx1
Issue Date: 1-Jun-2009
Citation: Jacob, B., Osato, M. (2009-06-01). Stem cell exhaustion and leukemogenesis. Journal of Cellular Biochemistry 107 (3) : 393-399. ScholarBank@NUS Repository. https://doi.org/10.1002/jcb.22150
Abstract: Cancer is the result of a combination of genetic alterations, which aid transformation of cells. However, oncogenic alterations also simultaneously induce some detrimental effects on the cells such as apoptosis, senescence, and differentiation. Such negative effects caused by certain oncogenic events are overcome by other cooperating genetic hits. We propose stem cell exhaustion as a novel detrimental effect that is caused by a wide variety of oncogenic alterations. Interestingly, in most cases, the stem cell exhaustion due to oncogenic alterations is preceded by an abnormal expansion of stem/progenitor cells. This preceding stem/progenitor cell expansion may be a key feature that still promotes cancer development, along with cooperating hits that rescue stem cell exhaustion. This review summarizes current knowledge about hematopoietic stem cell exhaustion and the mechanisms to overcome stem cell exhaustion in cancer development. © 2009 Wiley-Liss, Inc.
Source Title: Journal of Cellular Biochemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/116178
ISSN: 07302312
DOI: 10.1002/jcb.22150
Appears in Collections:Staff Publications

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