Please use this identifier to cite or link to this item:
Title: Total synthesis of the fumiquinazoline alkaloids: Solid-phase studies
Authors: Wang, H. 
Ganesan, A. 
Issue Date: Mar-2000
Citation: Wang, H.,Ganesan, A. (2000-03). Total synthesis of the fumiquinazoline alkaloids: Solid-phase studies. Journal of Combinatorial Chemistry 2 (2) : 186-194. ScholarBank@NUS Repository.
Abstract: We have previously described an efficient four-step synthesis of the fumiquinazoline alkaloids (Wang, H.; Ganesan, A. J. Org. Chem. 1998, 63, 2432-2433). Here, we demonstrate that this route is readily adaptable to combinatorial synthesis on solid phase. Linear tripeptides containing a central anthranilate unit were assembled on the Wang resin and subjected to dehydration and cyclative release to yield the pyrazino[2,1-b]quinazoline-3,6-diones in high purity. To demonstrate the scope of this protocol, a small library [ca. 20 compounds] of unnatural analogues was prepared by parallel synthesis.
Source Title: Journal of Combinatorial Chemistry
ISSN: 15204766
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

checked on Nov 8, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.