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|Title:||Total synthesis of the fumiquinazoline alkaloids: Solid-phase studies|
|Authors:||Wang, H. |
|Source:||Wang, H.,Ganesan, A. (2000-03). Total synthesis of the fumiquinazoline alkaloids: Solid-phase studies. Journal of Combinatorial Chemistry 2 (2) : 186-194. ScholarBank@NUS Repository.|
|Abstract:||We have previously described an efficient four-step synthesis of the fumiquinazoline alkaloids (Wang, H.; Ganesan, A. J. Org. Chem. 1998, 63, 2432-2433). Here, we demonstrate that this route is readily adaptable to combinatorial synthesis on solid phase. Linear tripeptides containing a central anthranilate unit were assembled on the Wang resin and subjected to dehydration and cyclative release to yield the pyrazino[2,1-b]quinazoline-3,6-diones in high purity. To demonstrate the scope of this protocol, a small library [ca. 20 compounds] of unnatural analogues was prepared by parallel synthesis.|
|Source Title:||Journal of Combinatorial Chemistry|
|Appears in Collections:||Staff Publications|
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