Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2008.08.001
Title: BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients
Authors: Ang, P.W.
Li, W.Q. 
Soong, R. 
Iacopetta, B.
Keywords: APC
BRAF
CIMP
Colorectal cancer
Issue Date: 18-Jan-2009
Citation: Ang, P.W., Li, W.Q., Soong, R., Iacopetta, B. (2009-01-18). BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients. Cancer Letters 273 (2) : 221-224. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2008.08.001
Abstract: This study investigated the relationship between BRAF mutation, the CpG island methylator phenotype (CIMP+) and APC methylation in colorectal cancer (CRC) from young patients. The V600E BRAF mutation was found in 7% of cases and was strongly associated with the tumour features of proximal site, advanced stage and poor histological grade. More than half (53%) the tumours with BRAF mutation were also CIMP+ as evaluated by a standard panel of markers, compared to only 4% of tumours with wildtype BRAF (P < 0.0001). In contrast to CIMP+, APC methylation was inversely correlated with BRAF mutation (P = 0.02). BRAF mutation and CIMP+ are therefore likely to be involved in an alternate, albeit rare, pathway to APC inactivation during the development of CRC in younger patients. © 2008 Elsevier Ireland Ltd. All rights reserved.
Source Title: Cancer Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/115013
ISSN: 03043835
DOI: 10.1016/j.canlet.2008.08.001
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