Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2008.08.001
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dc.titleBRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients
dc.contributor.authorAng, P.W.
dc.contributor.authorLi, W.Q.
dc.contributor.authorSoong, R.
dc.contributor.authorIacopetta, B.
dc.date.accessioned2014-12-12T07:09:58Z
dc.date.available2014-12-12T07:09:58Z
dc.date.issued2009-01-18
dc.identifier.citationAng, P.W., Li, W.Q., Soong, R., Iacopetta, B. (2009-01-18). BRAF mutation is associated with the CpG island methylator phenotype in colorectal cancer from young patients. Cancer Letters 273 (2) : 221-224. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2008.08.001
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/115013
dc.description.abstractThis study investigated the relationship between BRAF mutation, the CpG island methylator phenotype (CIMP+) and APC methylation in colorectal cancer (CRC) from young patients. The V600E BRAF mutation was found in 7% of cases and was strongly associated with the tumour features of proximal site, advanced stage and poor histological grade. More than half (53%) the tumours with BRAF mutation were also CIMP+ as evaluated by a standard panel of markers, compared to only 4% of tumours with wildtype BRAF (P < 0.0001). In contrast to CIMP+, APC methylation was inversely correlated with BRAF mutation (P = 0.02). BRAF mutation and CIMP+ are therefore likely to be involved in an alternate, albeit rare, pathway to APC inactivation during the development of CRC in younger patients. © 2008 Elsevier Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.canlet.2008.08.001
dc.sourceScopus
dc.subjectAPC
dc.subjectBRAF
dc.subjectCIMP
dc.subjectColorectal cancer
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1016/j.canlet.2008.08.001
dc.description.sourcetitleCancer Letters
dc.description.volume273
dc.description.issue2
dc.description.page221-224
dc.description.codenCALED
dc.identifier.isiut000262582100005
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