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Title: Aflatoxin B1-induced 8-hydroxydeoxyguanosine formation in rat hepatic DNA
Authors: Shen, H.-M. 
Ong, C.-N. 
Lee, B.-L.
Shi, C.-Y.
Issue Date: 1995
Citation: Shen, H.-M.,Ong, C.-N.,Lee, B.-L.,Shi, C.-Y. (1995). Aflatoxin B1-induced 8-hydroxydeoxyguanosine formation in rat hepatic DNA. Carcinogenesis 16 (2) : 419-422. ScholarBank@NUS Repository.
Abstract: A time- and dose-dependent increase in 8-hydroxydeoxy-guanosine (8-OHdG) was observed in rat hepatic DNA after a single i.p. injection of aflatoxin B1 (AFB1). It was also found that pre-treatment with selenium or deferoxamine significantly reduced 8-OHdG level in AFB1-administered rats. In contrast, no reduction in 8-OHdG concentration was found in vitamin E-pre-treated rats. These results provide evidence that AFB1 causes oxidative DNA damage in rat liver, which may involve hydroxyl radicals as the initiating species. It is postulated that AFB1-induced oxidative DNA damage (8-OHdG formation) may constitute an important pathway in AFB1 hepatocarcinogenesis.
Source Title: Carcinogenesis
ISSN: 01433334
Appears in Collections:Staff Publications

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