Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/113349
DC FieldValue
dc.titleAflatoxin B1-induced 8-hydroxydeoxyguanosine formation in rat hepatic DNA
dc.contributor.authorShen, H.-M.
dc.contributor.authorOng, C.-N.
dc.contributor.authorLee, B.-L.
dc.contributor.authorShi, C.-Y.
dc.date.accessioned2014-12-01T06:53:29Z
dc.date.available2014-12-01T06:53:29Z
dc.date.issued1995
dc.identifier.citationShen, H.-M.,Ong, C.-N.,Lee, B.-L.,Shi, C.-Y. (1995). Aflatoxin B1-induced 8-hydroxydeoxyguanosine formation in rat hepatic DNA. Carcinogenesis 16 (2) : 419-422. ScholarBank@NUS Repository.
dc.identifier.issn01433334
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/113349
dc.description.abstractA time- and dose-dependent increase in 8-hydroxydeoxy-guanosine (8-OHdG) was observed in rat hepatic DNA after a single i.p. injection of aflatoxin B1 (AFB1). It was also found that pre-treatment with selenium or deferoxamine significantly reduced 8-OHdG level in AFB1-administered rats. In contrast, no reduction in 8-OHdG concentration was found in vitamin E-pre-treated rats. These results provide evidence that AFB1 causes oxidative DNA damage in rat liver, which may involve hydroxyl radicals as the initiating species. It is postulated that AFB1-induced oxidative DNA damage (8-OHdG formation) may constitute an important pathway in AFB1 hepatocarcinogenesis.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCOMMUNITY,OCCUPATIONAL & FAMILY MEDICINE
dc.description.sourcetitleCarcinogenesis
dc.description.volume16
dc.description.issue2
dc.description.page419-422
dc.description.codenCRNGD
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.