Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/112820
Title: Novel hepatocyte encapsulation enhances cellular functions
Authors: Chia, Ser-Mien 
Li, Jun 
Xu, Xi
Gao, Shujun
Leong, Kam W. 
Yu, Hanry 
Issue Date: 1999
Citation: Chia, Ser-Mien,Li, Jun,Xu, Xi,Gao, Shujun,Leong, Kam W.,Yu, Hanry (1999). Novel hepatocyte encapsulation enhances cellular functions. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 2 : 722-. ScholarBank@NUS Repository.
Abstract: We have synthesized a HEMA, MMA & MAA terpolymer to complex with modified collagen for encapsulation of rat hepatocytes. The encapsulated hepatocytes exhibited high level of functions in culture comparable to those of hepatocyte spheroids. The collagen that lined the inner layer of the capsule provided a compatible substrate for hepatocyte culture, and the outer terpolymer shell determined permeability, which was optimized for transport of 60kDa but not 150kDa molecules. Beside shorter processing time than spheroid formation, the encapsulation may offer other advantages important in designing a bioartificial liver-assisted device.
Source Title: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
URI: http://scholarbank.nus.edu.sg/handle/10635/112820
ISBN: 0780356756
ISSN: 05891019
Appears in Collections:Staff Publications

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