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Title: Gender-specific association of insertion/deletion polymorphisms in the nogo gene and chronic schizophrenia
Authors: Tan, E.-C. 
Chong, S.-A.
Wang, H.
Lim, E.C.-P.
Teo, Y.-Y.
Keywords: Chinese
Genetic polymorphism
Issue Date: 3-Oct-2005
Citation: Tan, E.-C., Chong, S.-A., Wang, H., Lim, E.C.-P., Teo, Y.-Y. (2005-10-03). Gender-specific association of insertion/deletion polymorphisms in the nogo gene and chronic schizophrenia. Molecular Brain Research 139 (2) : 212-216. ScholarBank@NUS Repository.
Abstract: Nogo is a myelin-associated protein associated with neurite outgrowth and regeneration. A previous study has reported an association between an insertion/deletion polymorphism in schizophrenia. We tested for the distribution of the polymorphism and haplotypes of this and another insertion/deletion polymorphism in our population. We have also developed an assay combining allele-specific polymerase chain reaction (AS-PCR) and restriction fragment length polymorphism (RFLP) to simultaneously type these two insertion/deletion polymorphisms. There was a statistically significant difference at the allelic level for both the CAA (χ2 = 4.378, df = 1, P value = 0.036) and TATC (χ2 = 5.807, df = 1, P = 0.016) polymorphisms in the female subgroup, but not in males. With our genotyping method, we also determined the molecular haplotype. Within the female gender, odds ratio is at 1.57 (95% CI 1.05-2.37) for CAACAA-TATC and 1.40 (95% CI 0.55-3.60) for CAA-TATC, the two at-risk haplotypes. Odds ratio is 0.63 (95% CI 0.42-0.93) for the protective wildtype haplotype CAA-TATCTATC. Further study of these two polymorphisms to investigate functional significance and confirm gender-specific association should be carried out. © 2005 Elsevier B.V. All rights reserved.
Source Title: Molecular Brain Research
ISSN: 0169328X
DOI: 10.1016/j.molbrainres.2005.05.010
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