Please use this identifier to cite or link to this item:
|Title:||Gender-specific association of insertion/deletion polymorphisms in the nogo gene and chronic schizophrenia|
|Authors:||Tan, E.-C. |
|Source:||Tan, E.-C., Chong, S.-A., Wang, H., Lim, E.C.-P., Teo, Y.-Y. (2005-10-03). Gender-specific association of insertion/deletion polymorphisms in the nogo gene and chronic schizophrenia. Molecular Brain Research 139 (2) : 212-216. ScholarBank@NUS Repository. https://doi.org/10.1016/j.molbrainres.2005.05.010|
|Abstract:||Nogo is a myelin-associated protein associated with neurite outgrowth and regeneration. A previous study has reported an association between an insertion/deletion polymorphism in schizophrenia. We tested for the distribution of the polymorphism and haplotypes of this and another insertion/deletion polymorphism in our population. We have also developed an assay combining allele-specific polymerase chain reaction (AS-PCR) and restriction fragment length polymorphism (RFLP) to simultaneously type these two insertion/deletion polymorphisms. There was a statistically significant difference at the allelic level for both the CAA (χ2 = 4.378, df = 1, P value = 0.036) and TATC (χ2 = 5.807, df = 1, P = 0.016) polymorphisms in the female subgroup, but not in males. With our genotyping method, we also determined the molecular haplotype. Within the female gender, odds ratio is at 1.57 (95% CI 1.05-2.37) for CAACAA-TATC and 1.40 (95% CI 0.55-3.60) for CAA-TATC, the two at-risk haplotypes. Odds ratio is 0.63 (95% CI 0.42-0.93) for the protective wildtype haplotype CAA-TATCTATC. Further study of these two polymorphisms to investigate functional significance and confirm gender-specific association should be carried out. © 2005 Elsevier B.V. All rights reserved.|
|Source Title:||Molecular Brain Research|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 28, 2018
WEB OF SCIENCETM
checked on Feb 21, 2018
checked on Feb 27, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.